Corneal Cross-Linking in Pediatric Patients With Progressive Keratoconus
| Autor: | Martin McCarthy, Paul J. Dubord, Karolien Termote, Stephanie J. Wise, Christian Diaz, Sonia N. Yeung |
|---|---|
| Přispěvatelé: | Ophtalmology - Eye surgery |
| Rok vydání: | 2016 |
| Předmět: |
Male
Keratoconus medicine.medical_specialty Visual acuity Distance visual acuity Adolescent genetic structures Visual Acuity/physiology Ultraviolet Rays Corneal Stroma Riboflavin Visual Acuity Spherical equivalent Refraction Ocular law.invention 03 medical and health sciences 0302 clinical medicine law Ophthalmology Collagen/metabolism medicine Corneal Stroma/metabolism Humans Child Refraction Ocular/physiology Retrospective Studies Medicine(all) Photosensitizing Agents Keratometer business.industry Keratoconus/drug therapy Retrospective cohort study Mean age Riboflavin/therapeutic use medicine.disease eye diseases Aberrations of the eye Cross-Linking Reagents Photochemotherapy Disease Progression 030221 ophthalmology & optometry Female Collagen sense organs medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Cornea. 35:1441-1443 |
| ISSN: | 0277-3740 |
| Popis: | Purpose To evaluate corneal cross-linking (CXL) in the treatment of keratoconus in pediatric patients. Specifically, this study investigates the impact of CXL on uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (BDVA), manifest refraction, keratometry (K) measurements, and higher order aberrations. Methods This is a retrospective, observational case series of patients 18 years old or younger with progressive keratoconus who underwent CXL from January 2009 to August 2013. Preoperative and 1-year postoperative data including BDVA, manifest refraction, mean K readings, and corneal aberration measurements were extracted from clinical charts and topographical imaging. Visual acuity was converted to logarithm of the minimum angle of resolution (logMAR) scale, and mean refractive spherical equivalent (MRSE) was calculated from manifest refraction. Results The group consisted of 39 eyes from 28 patients, including 21 males and 7 females (mean age = 16.3 years, range: 11-18, standard deviation [SD] = 1.81). UDVA did not change significantly (preoperative UDVA = 1.20 logMAR, SD = 0.57, and postoperative UDVA = 0.90 logMAR, SD = 0.67, P = 0.19). BDVA did not change significantly (preoperative BDVA = 0.34 logMAR, SD = 0.27, and postoperative BDVA = 0.34 logMAR, SD = 0.23, P = 0.50). There was no significant change in mean K (preoperative K = 48.49, SD = 5.44, and postoperative K = 48.25, SD = 4.74, P = 0.34). Mean MRSE did not change significantly (preoperative MRSE = -3.29 D, SD = 4.04, and postoperative MRSE = -3.53 D, SD = 4.07, P = 0.31). Corneal aberration measurements were available for 10 eyes, and stability of measurements was demonstrated. There were no complications noted. Conclusions This study suggests that CXL is a safe and effective procedure that halts the progression of keratoconus in pediatric patients at 1-year follow-up. To validate these findings, longer follow-up is required. |
| Databáze: | OpenAIRE |
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