Primary and secondary pulmonary hypertension in systemic lupus erythematosus
| Autor: | T L Pan, Julian Thumboo, M L Boey |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypertension Pulmonary 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine.artery Humans Lupus Erythematosus Systemic Medicine Aged Aged 80 and over 030203 arthritis & rheumatology Singapore Lupus erythematosus Systemic lupus erythematosus business.industry valvular heart disease Interstitial lung disease Retrospective cohort study Middle Aged medicine.disease Pulmonary hypertension Surgery Pulmonary embolism Pulmonary artery Cardiology Female business |
| Zdroj: | Lupus. 9:338-342 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1191/096120300678828361 |
| Popis: | Objectives: To describe the aetiology and clinical profile of primary and secondary pulmonary hypertension (PHT) in SLE patients. Methods: A retrospective study of SLE patients with PHT identified from a cohort of 786 SLE patients seen at Tan Tock Seng Hospital, Singapore. Results: 22 patients had primary and 24 patients had secondary PHT, with similar clinical features at presentation and a similar degree of pulmonary pressure elevation. Secondary PHT was due to valvular heart disease (50%), pulmonary embolism (13%), interstitial lung disease (8%) or a combination of these factors (29%). Primary PHT tended to present after a shorter duration of lupus than secondary PHT (8.8 vs 43.2 months, P = 0.118). At presentation, Raynaud's phenomenon was present in 34.8% of subjects with primary or secondary PHT. Among those with secondary PHT, the presence of Raynaud's phenomenon was associated with a trend towards higher pulmonary artery systolic pressures (51.0 vs 40.5 mmHg, P = 0.101). 17% of patients with PHT died, but from causes unrelated to PHT. Conclusion: Primary and secondary PHT are equally common in SLE patients. Secondary PHT is often multi-factorial, and Raynaud's phenomenon may be a marker for the severity of PHT in this group of patients. |
| Databáze: | OpenAIRE |
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