Anti-Mullerian Hormone and Inhibin B Levels in Obese Boys; Relations with Cardiovascular Risk Factors
| Autor: | S. Sami Erdem, Hüseyin Kurku, Isa Deniz, Müge Atar, Muammer Buyukinan, Ozgur Pirgon |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Anti-Mullerian Hormone
Male endocrine system medicine.medical_specialty Adolescent Endothelium Endocrinology Diabetes and Metabolism medicine.medical_treatment Aortic Diseases 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Internal Medicine medicine Humans Inhibins Testosterone Obesity Sertoli Cells 030219 obstetrics & reproductive medicine biology business.industry Insulin Anti-Müllerian hormone General Medicine medicine.disease Sertoli cell C-Reactive Protein medicine.anatomical_structure Cardiovascular Diseases biology.protein Endothelium Vascular Insulin Resistance business Biomarkers Homeostasis |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 126:528-533 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0044-101141 |
| Popis: | Objective Obesity may reduce sertoli cell functions in men. The aim of the study was to investigate antimullerian hormone (AMH) and inhibin B levels (sertoli cell markers) in obese boys and their relations to cardiovascular risk factors such as insulin sensitivity index, aortic intima media thickness (aIMT) and high sensitive c-reactive protein (hsCRP). Patients, methods 121 obese and 38 healthy lean adolescents were included in the study. Serum AMH, inhibin B, gonadotropins, total testosterone, lipids, hsCRP, glucose and insulin levels were detected and analyzed. Insulin resistance was analyzed using the homeostasis model assessment (HOMA-IR). aIMT was measured by high-resolution B-mode ultrasonography. Results Serum AMH, inhibin B and total testosterone levels were lower in the obese adolescents (p=0.01, p=0.009 and p=0.002, respectively). aIMT measurements (p Conclusion We found that concentrations of both sertoli cell markers (AMH and inhibin B) were significantly lower in obese pubertal boys especially in obese with IR. Obesity and IR might be important factors for the sertoli cell impairment in pubertal boys. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|