Hemoglobin A1C Levels are Independently Associated with the Risk of Coronary Atherosclerotic Plaques in Patients without Diabetes: A Cross-Sectional Study
| Autor: | Po Hsun Huang, Wan Leong Chan, Chung-Chi Lin, Yuan Jen Wang, Ying Wen Wang, Hsin Bang Leu, Shao Sung Huang, Yaw Zon Ding, Pai Feng Hsu, Shing Jong Lin, Tse Min Lu, Jaw Wen Chen, Wei Ting Wang, Teh Ling Liou |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study Taiwan Coronary Artery Disease 030204 cardiovascular system & hematology Severity of Illness Index Asymptomatic Coronary artery disease 03 medical and health sciences 0302 clinical medicine High-density lipoprotein cholesterol Predictive Value of Tests Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Coronary computed tomography angiography Low-density lipoprotein cholesterol Glycated Hemoglobin Atherosclerotic plaque business.industry Biochemistry (medical) Non-diabetic Cholesterol LDL Middle Aged medicine.disease Coronary Vessels Plaque Atherosclerotic Stenosis Cross-Sectional Studies Blood pressure Cardiology Population study Female Original Article medicine.symptom Cardiology and Cardiovascular Medicine business Body mass index Biomarkers 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Atherosclerosis and Thrombosis |
| ISSN: | 1880-3873 1340-3478 |
| DOI: | 10.5551/jat.51425 |
| Popis: | Aim: Coronary atherosclerotic plaques can be detected in asymptomatic subjects and are related to low-density lipoprotein cholesterol (LDL) levels in patients with coronary artery disease. However, researchers have not yet determined the associations between various plaque characteristics and other lipid parameters, such as HDL-C and TG levels, in low-risk populations. Methods: One thousand sixty-four non-diabetic subjects (age, 57.86 ± 9.73 years; 752 males) who underwent coronary computed tomography angiography (CCTA) were enrolled and the severity and patterns of atherosclerotic plaques were analyzed. Results: Statin use was reported by 25% of the study population, and subjects with greater coronary plaque involvement (segment involvement score, SIS) were older and had a higher body mass index (BMI), blood pressure, unfavorable lipid profiles and comorbidities. After adjusting for comorbidities, only age (β = 0.085, p < 0.001), the male gender (β = 1.384, p < 0.001), BMI (β = 0.055, p = 0.019) and HbA1C levels (β = 0.894, p < 0.001) were independent factors predicting the greater coronary plaque involvement in non-diabetic subjects. In the analysis of significantly different (> 50%) stenosis plaque patterns, age (OR: 1.082, 95% CI: 10.47–1.118) and a former smoking status (OR: 2.061, 95% CI: 1.013–4.193) were independently associated with calcified plaques. For partial calcified (mixed type) plaques, only age (OR: 1.085, 95% CI: 1.052–1.119), the male gender (OR: 7.082, 95% CI: 2.638–19.018), HbA1C levels (OR: 2.074, 95% CI: 1.036–4.151), and current smoking status (OR: 1.848, 95% CI: 1.089–3.138) were independently associated with the risk of the presence of significant stenosis in mixed plaques. Conclusions: A higher HbA1c levels is independently associated with the presence and severity of coronary artery atherosclerosis in non-diabetic subjects, even when LDL-C levels are tightly controlled. |
| Databáze: | OpenAIRE |
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