DrosophilaEmbryos as a Model for Wound-Induced Transcriptional Dynamics: Genetic Strategies to Achieve a Localized Wound Response
| Autor: | Michelle T. Juarez |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics integumentary system biology Activator (genetics) Embryo Critical Care and Intensive Care Medicine biology.organism_classification Genetic pathways Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Wound response Gene expression Emergency Medicine Issue Editor: Michael J. GalkoCritical Reviews Wound induced Drosophila melanogaster 030217 neurology & neurosurgery Organism |
| Zdroj: | Advances in Wound Care. 5:262-270 |
| ISSN: | 2162-1934 2162-1918 |
| Popis: | While many studies have established a paradigm for tissue repair at the level of cellular remodeling, it is not clear how an organism restricts a response only to the injured region of a damaged tissue. Skin, the largest organ in the human body, is prone to injury, and repair of epidermal tissue represents a medically relevant system to investigate. Significance: Studies in Drosophila melanogaster provide a robust genetic system to identify molecular components that will positively impact repair and healing. The Drosophila skin consists of a single-cell epidermal layer and relies on well-conserved cellular mechanisms to coordinate gene expression during development. Many studies have established that key developmental genes promote a response to epidermal injury, but the balance between activator and inhibitor signals to coordinate a localized response remains unknown. Recent Advances: Discovery of a genetic pathway that promotes the restriction of transcriptional response to damage only in effected regio... |
| Databáze: | OpenAIRE |
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