The evolution of 5S RNA secondary structures

Autor:	David Sankoff, Anne-Marie Morin, R. J. Cedergren
Rok vydání:	1978
Předmět:	RNA Hydrogen Bonding General Medicine Computational biology Biology Plants Bioinformatics Biological Evolution Cell Line RNA Bacterial Eukaryotic Cells Prokaryotic Cells RNA Ribosomal Animals Nucleic Acid Conformation Thermodynamics Protein secondary structure
Zdroj:	Canadian journal of biochemistry. 56(6)
ISSN:	0008-4018
Popis:	We have applied the Pipas–McMahon algorithm based on free energy calculations to the search for a 5S RNA base-pair structure common to all known sequences. We find that a 'Y'-shaped model is consistently among the structures having the lowest free energy using 5S RNA sequences from either eukaryotic or prokaryotic sources. Comparison of this 'Y' structure with models which have recently been proposed show these models to be remarkably similar, and the minor differences are explicable based on the technique used to obtain the model. That prokaryotic and eukaryotic 5S RNA can adopt a similar secondary structure is strong support for its resistance to change during evolution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55770755c992028e74188c8421e2c562 https://pubmed.ncbi.nlm.nih.gov/667690 Zobrazit plný text záznamu