Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases
| Autor: | Arun Upadhyay |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Ubiquitin proteasome system
CASA chaperone-assisted selective autophagy DUBs deubiquitinases Review 0302 clinical medicine Ubiquitin Natural molecules Chaperones General Pharmacology Toxicology and Pharmaceutics Ub ubiquitin Cancer CAP chaperone-assisted proteasomal degradation EGCG epigallocatechin-3-gallate 0303 health sciences biology Drug discovery Chemistry HECT homologous to the E6-AP carboxyl terminus Neurodegeneration CELL DEBRIS CMA chaperone-mediated autophagy Cell biology 030220 oncology & carcinogenesis Proteinopathies HSP heat shock protein LAMP2a lysosome-associated membrane protein 2a UPS ubiquitin–proteasome system 17-AAG 17-allylamino-geldanamycin BAG BCL2-associated athanogene HSF1 heat shock factor 1 RM1-950 RING really interesting new gene 03 medical and health sciences ESCRT endosomal sorting complexes required for transport CHIP carboxy-terminus of HSC70 interacting protein medicine Autophagy HSC70 heat shock cognate 70 PQC protein quality control 030304 developmental biology APC anaphase-promoting complex medicine.disease NBR1 next to BRCA1 gene 1 KFERQ lysine-phenylalanine-glutamate-arginine-glutamine LC3 light chain 3 Ageing Proteostasis Proteasome biology.protein Therapeutics. Pharmacology |
| Zdroj: | Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2995-3014 (2021) Acta Pharmaceutica Sinica. B |
| ISSN: | 2211-3835 |
| Popis: | Cells have different sets of molecules for performing an array of physiological functions. Nucleic acids have stored and carried the information throughout evolution, whereas proteins have been attributed to performing most of the cellular functions. To perform these functions, proteins need to have a unique conformation and a definite lifespan. These attributes are achieved by a highly coordinated protein quality control (PQC) system comprising chaperones to fold the proteins in a proper three-dimensional structure, ubiquitin-proteasome system for selective degradation of proteins, and autophagy for bulk clearance of cell debris. Many kinds of stresses and perturbations may lead to the weakening of these protective cellular machinery, leading to the unfolding and aggregation of cellular proteins and the occurrence of numerous pathological conditions. However, modulating the expression and functional efficiency of molecular chaperones, E3 ubiquitin ligases, and autophagic proteins may diminish cellular proteotoxic load and mitigate various pathological effects. Natural medicine and small molecule-based therapies have been well-documented for their effectiveness in modulating these pathways and reestablishing the lost proteostasis inside the cells to combat disease conditions. The present article summarizes various similar reports and highlights the importance of the molecules obtained from natural sources in disease therapeutics. Graphical abstract Extra-/intracellular stresses challenge cellular health throughout life. Small natural molecules modulate the functioning of protein quality control components to maintain proteins' native structures and preserve cells’ proteome under healthy and stressful conditions.Image 1 |
| Databáze: | OpenAIRE |
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