The differential pathways of bone morphogenetic protein (BMP)-4 and -7 in the suppression of the bovine granulosa cell apoptosis
| Autor: | Akio Miyamoto, Takefumi Kayamori, Naomichi Kosaka, Takashi Shimizu |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
endocrine system
animal structures Granulosa cell Bone Morphogenetic Protein 7 Clinical Biochemistry Bone morphogenetic protein 8A bcl-X Protein Apoptosis X-Linked Inhibitor of Apoptosis Protein Bone Morphogenetic Protein 4 Biology Bone morphogenetic protein Survivin Animals Humans Molecular Biology Cells Cultured bcl-2-Associated X Protein Deoxyribonucleases Granulosa Cells Caspase 3 Bone morphogenetic protein 10 Cell Biology General Medicine Caspase 9 BMPR2 Bone morphogenetic protein 7 embryonic structures Cancer research Cattle Female Apoptosis Regulatory Proteins Microtubule-Associated Proteins |
| Zdroj: | Molecular and cellular biochemistry. 323(1-2) |
| ISSN: | 1573-4919 |
| Popis: | Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor-beta family, are crucial factors in follicular growth and development in the mammalian ovary. In this study, we examined the effects of BMP-4 and BMP-7 on granulosa cell apoptosis. Here, we report that BMP-7 suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD. Our data provide the first evidence that BMP-4 and BMP-7 may inhibit granulosa cell apoptosis via different pathways. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink