Adipocytokine concentrations in children with different types of beta-thalassemia
| Autor: | Yasemin Isik Balci, Yasar Enli, Aziz Polat, Ebru Uzun, Cafer Gönen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Thalassemia Clinical Biochemistry Adipose tissue Disease Visfatin Adipocytokine preschool child RETN protein human hemic and lymphatic diseases cytokine Resistin Child Nicotinamide Phosphoribosyltransferase thalassemia minor anthropometry beta thalassemia childhood disease article correlational study Beta thalassemia General Medicine Adiponectin/*blood Adolescent Case-Control Studies Child Preschool Cytokines/*blood Humans Nicotinamide Phosphoribosyltransferase/*blood Resistin/*blood beta-Thalassemia/*blood/etiology female priority journal erythrocyte count thalassemia major Cytokines ADIPOQ protein human disease severity Adiponectin hormones hormone substitutes and hormone antagonists medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities hematocrit Adipokine blood transfusion Beta-thalassemia thalassemia intermedia blood Internal medicine medicine Endocrine system controlled study human adiponectin hemoglobin blood level business.industry beta-Thalassemia nutritional and metabolic diseases hemoglobin case control study medicine.disease major clinical study Endocrinology Immunology nicotinamide phosphoribosyltransferase human business |
| Popis: | Background. Beta-thalassemia is an inherited blood disorder. It results from the impaired production of ß-globin chains, leading to a relative excess of alpha-globin chains. Clinical severity separates this disease into three main subtypes: ß- thalassemia major, ß-thalassemia intermedia and ß-thalassemia minor, the former two being clinically more significant. Inflammatory processes may play an important role in some of the complications of thalassemia. Adipose tissue is one of the most important endocrine and secretory organs that release adipocytokines like adiponectin, resistin and visfatin. Aim. The aim of our study was to analyze adipocytokine concentrations (adiponectin, resistin and visfatin) in different types of ß-thalassemia patients and determine any possible correlations with disease severity. Methods. We recruited 29 patients who were transfusion-dependent ß-thalassemia- major patients, 17 patients with ß-thalassemia intermedia, 30 ß-thalassemia minor patients. The control group consisted of 30 healthy children. Anthropometric measurements, complete blood count, biochemical parameters, serum concentrations of adiponectin, resistin, visfatin were performed for all subjects. Results. Resistin and visfatin concentrations were significantly higher in ß-thalassemia minor patients than in controls. Adiponectin, resistin and visfatin concentrations were significantly higher in both ß-thalassemia intermedia and major patients than in controls. The concentrations of adiponectin, resistin and visfatin were significantly higher in both ß-thalassemia intermedia and major patients than in ß-thalassemia minor patients. There was no significant difference between ß-thalassemia intermedia and ß-thalassemia major patients for adipocytokines concentrations. Conclusion. We speculate that these adipocytokines may play a role in the development of complications in ß-thalassaemia. © 2014 Informa Healthcare. |
| Databáze: | OpenAIRE |
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