Joint effect of smoking and NQO1 C609T polymorphism on undifferentiated nasopharyngeal carcinoma risk in a North African population
| Autor: | Elham Hassen, Abdellatif Benider, M. Hamdi-Cherif, K. Boualga, Wided Ben Ayoub, Marilys Corbex, Meriem Khyatti, Khalid Moumad, Wafa Khaali, El Khalil Ben Driss |
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| Přispěvatelé: | Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP), Université Abdelmalek Essaâdi (UAE), CHU Ibn Rochd [Casablanca], Association Tunisienne de Lutte Contre le Cancer, Centre Hospito-Universitaire de Sétif, Centre Anti-Cancer de Blida (CAC Blida), Centre Hospitalo-Universitaire de Blida (CHU Blida), Université de Monastir - University of Monastir (UM), WHO Regional Office for Europe [Copenhagen], This study was supported by the Association for International Cancer Research (grant number 03‐252) and the Cancer Research Institute (grant number 201932). |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Population Polymorphism Single Nucleotide Virus smoking 03 medical and health sciences 0302 clinical medicine Africa Northern Internal medicine Genotype Genetics medicine Genetic predisposition NAD(P)H Dehydrogenase (Quinone) [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Humans Allele education Molecular Biology Allele frequency Gene Genetics (clinical) education.field_of_study business.industry nasopharyngeal carcinoma Nasopharyngeal Neoplasms Original Articles Middle Aged medicine.disease North Africa 3. Good health 030104 developmental biology Nasopharyngeal carcinoma 030220 oncology & carcinogenesis NQO1 polymorphism Female Original Article business |
| Zdroj: | Molecular Genetics and Genomic Medicine Molecular Genetics and Genomic Medicine, Wiley, 2018, ⟨10.1002/mgg3.461⟩ Molecular Genetics & Genomic Medicine |
| ISSN: | 2324-9269 |
| DOI: | 10.1002/mgg3.461⟩ |
| Popis: | International audience; BACKGROUND:Nasopharyngeal carcinoma (NPC) has a higher incidence in North Africa than in most parts of the world. In addition to environmental factors such as Epstein-Barr virus infection and chemical carcinogen exposure, genetic susceptibility has been reported to play a key role in the development of NPC. NAD(P)H: quinone oxidoreductase 1 is a cytosolic enzyme that protects cells from oxidative damage. A C to T transition at position 609 in the NQO1 gene (OMIM: 125860) has been shown to alter the enzymatic activity of the enzyme and has been associated with increased risk to several cancers. This study investigates for the first time the effect of this polymorphism on NPC susceptibility in a North African population.METHODS:The NQO1 C609T polymorphism was genotyped using PCR-RFLP in 392 NPC cases and 365 controls from Morocco, Algeria, and Tunisia.RESULTS:The allele frequencies and distributions of genotypes did not differ between cases and controls (p > 0.05). When stratifying according to smoking status, we observed two-fold higher NPC risk in ever-smokers carrying the CT or TT genotype. Multiple logistic regression analysis revealed that there was a significant interaction between T allele and smoking status (OR = 1.95, 95% CI = 1.20-3.19; interaction p = 0.007).CONCLUSION:In this North African population, the functional NQO1 polymorphism was associated with a significantly higher risk of NPC among smokers and did not affect the risk among nonsmokers. |
| Databáze: | OpenAIRE |
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