Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
| Autor: | Fatih Dede, Serhan Piskinpasa, Ezgi Coskun Yenigun, Didem Turgut, Nihal Aydemir |
|---|---|
| Přispěvatelé: | [Belirlenecek] |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinary system Urology cut-off value Renal function 030204 cardiovascular system & hematology urologic and male genital diseases Article 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Lipocalin-2 Reference Values medicine Humans Prospective Studies Aged 0303 health sciences Creatinine Kidney 030306 microbiology business.industry postrenal Acute kidney injury General Medicine Middle Aged medicine.disease medicine.anatomical_structure Cross-Sectional Studies chemistry ROC Curve urinary neutrophil gelatinase-associated lipocalin (uNGAL) Etiology Biomarker (medicine) Female Kidney Diseases business Biomarkers Kidney disease |
| Zdroj: | Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 1300-0144 |
| Popis: | Background/aim: Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off value of uNGAL that can be used in the differential diagnosis of underlying AKI etiologies. Materials and methods: In this prospective cross-sectional study, we examined 82 subjects in four groups: patients that had (1) postrenal AKI; (2) AKI other than postrenal etiologies; (3) stable chronic kidney disease; and (4) healthy subjects. A renal function assessment was carried out by measuring serum creatininc (sCr) and uNGAL at the time of diagnosis [0th min (T0)]. We followed the study group for three months. Results: At the time of diagnosis, sCr (T0) was highest in the postrenal AKI and AKI groups in contrast to stable chronic kidney disease patients and healthy subjects (P < 0.001), as expected. T0 median uNGAL was highest in the postrenal group (P < 0.001). Area under curve (AUC) of uNGAL to estimate postrenal AKI presence was 0.957 (95% CI, 0.897-1.000; P < 0.001). The cut-off point of uNGAL was 42.625 ng/mL for this estimation. Conclusion: Patients with AKI must be classified according to the underlying etiologies as soon as possible. uNGAL may be useful to estimate the etiologies, and whether the problem is acute or chronic in the course. In postrenal kidney problems, to plan the urgency of the urologic procedures, it is crucial. WOS:000582190800010 2-s2.0-85093663120 PubMed: 32927927 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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