A phase II study of timed sequential therapy of acute myelogenous leukemia (AML) for patients over the age of 60: two cycle timed sequential therapy with topotecan, ara-C and mitoxantrone in adults with poor-risk AML
| Autor: | Chuanfa Guo, Javier Bolaños-Meade, Ivana Gojo, Judith E. Karp |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Acute myelogenous leukemia (AML) Phases of clinical research Chronic myelomonocytic leukemia Disease-Free Survival Risk Factors Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Aged Demography Aged 80 and over Mitoxantrone business.industry Remission Induction Cytarabine Cytogenetics Myeloid leukemia Hematology Middle Aged medicine.disease Confidence interval Surgery Survival Rate Leukemia Myeloid Acute Treatment Outcome Myelodysplastic Syndromes Female Topotecan business medicine.drug |
| Zdroj: | Leukemia Research. 28:571-577 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2003.10.026 |
| Popis: | Acute myeloid leukemia (AML) in the elderly is a serious problem characterized by poor response to therapy and short survival. To improve response to therapy, a timed sequential therapy (TST) approach was designed utilizing topotecan, cytosine arabinoside (ara-C) and mitoxantrone based on multiple studies suggesting that topotecan and mitoxantrone are effective in older patients. Thirty-two adults, ≥60-year-old (median age 69) were included. None had favorable cytogenetics and 44% had and antecedent myelodysplastic syndrome (MDS) or 2° AML. Fifty-nine percent achieved a complete response (CR). Median overall survival (OS) was 6.5 months (95% confidence interval (CI): 3.1–12.0 months; range, 15 days to 25.3 months). Disease-free survival (DFS) for the 19 patients achieving a CR was 7.7 months (95% CI: 6.1–13.7 months; range, 2.9–25.3 months). There were no differences in OS or DFS between cytogenetic or disease etiology groups. Although TST was well tolerated, long-term results in this group of patients are not satisfactory and new approaches are needed. |
| Databáze: | OpenAIRE |
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