Improving sensitivity of oral fluid testing in IgG prevalence studies: application of mixture models to a rubella antibody survey
| Autor: | N. J. GAY, A. J. VYSE, F. ENQUSELASSIE, W. NIGATU, D. J. NOKES |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Adolescent Epidemiology 030231 tropical medicine Rubella antibody Antibodies Viral medicine.disease_cause Sensitivity and Specificity Rubella Serology 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies medicine Humans 030212 general & internal medicine Child Aged QR355 Aged 80 and over Likelihood Functions biology business.industry Mouth Mucosa Infant Rubella virus Middle Aged medicine.disease Mixture model Infectious Diseases Child Preschool Immunoglobulin G Immunology biology.protein Oral fluid Viral disease Antibody business Research Article |
| Zdroj: | Epidemiology and Infection. 130:285-291 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268802008051 |
| Popis: | A method for the analysis of age-stratified antibody prevalence surveys is applied to a previously reported survey of antibody to rubella virus using oral fluid samples in which the sensitivity of the assay used was shown to be compromised. The age-specific distribution of the quantitative results of antibody tests using oral fluids is modelled as a mixture of strong positive, weak positive and negative components. This yields maximum likelihood estimates of the prevalence at each age and demonstrates that, when used in conjunction with mixture modelling techniques, the results of antibody prevalence studies using oral fluids accurately reflect those obtained using sera. |
| Databáze: | OpenAIRE |
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