International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: the EORTC QLQ-CML24
| Autor: | Mirjam A. G. Sprangers, François Guilhot, Lucien Noens, Marzia Salvucci, Giovanni Caocci, Michele Baccarani, Annarita Cardoni, Ourania Nicolatou-Galitis, Wei-Chu Chie, Massimo Breccia, Gianantonio Rosti, Fausto Castagnetti, Felice Bombaci, Stephan Pallua, Gregory A. Abel, Susanne Saussele, Adel Naeem, Simone Oerlemans, Giora Sharf, Kim Cocks, Franco Mandelli, Fabio Efficace |
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| Přispěvatelé: | Fabio Efficace, Michele Baccarani, Massimo Breccia, Susanne Saussele, Gregory Abel, Giovanni Caocci, Francois Guilhot, Kim Cock, Adel Naeem, Mirjam Spranger, Simone Oerleman, Weichu Chie, Fausto Castagnetti, Felice Bombaci, Giora Sharf, Annarita Cardoni, Lucien Noen, Stephan Pallua, Marzia Salvucci, Ourania Nicolatou-Galiti, Gianantonio Rosti, Franco Mandelli, Medical and Clinical Psychology, Cancer Center Amsterdam, Amsterdam Public Health, Medical Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychometrics International Cooperation Population MEDLINE Alpha interferon Piperazines Interviews as Topic Young Adult Quality of life Cronbach's alpha QUALITY OF LIFE Residence Characteristics Leukemia Myelogenous Chronic BCR-ABL Positive Surveys and Questionnaires medicine Health Status Indicators Humans Karnofsky Performance Status education Protein Kinase Inhibitors Aged Aged 80 and over education.field_of_study Descriptive statistics Questionnaire business.industry Chronic myeloid leukemia Public Health Environmental and Occupational Health Middle Aged humanities Pyrimidines Mood Imatinib mesylate Social Class Family medicine Benzamides Imatinib Mesylate Physical therapy Female INTERFERON-ALPHA business FOLLOW-UP |
| Zdroj: | Quality of Life Research, 23(3), 825-836. Springer Quality of life research, 23(3), 825-836. Springer Netherlands |
| ISSN: | 0962-9343 |
| Popis: | BackgroundHealth-related quality of life (HRQOL) is a key aspect for chronic myeloid leukemia (CML) patients. The aim of this study was to develop a disease-specific HRQOL questionnaire for patients with CML to supplement the European Organization for Research and Treatment of Cancer (EORTC)-QLQ C30.Patients and methodsThe process followed a predefined and systematic stepwise iterative process as defined by the EORTC guidelines for questionnaire development. The process was divided into 3 phases: (1) generation of relevant HRQOL issues, (2) operationalization of the HRQOL issues into a set of items, and (3) pretesting the questionnaire for relevance and acceptability. Descriptive statistics and psychometric analyses were also performed.ResultsOverall, 655 CML patients were enrolled in 10 countries including the USA and countries in Europe and Asia. Interviews with health-care professionals experienced in CML (n = 59) were also conducted. Results from the interviews, clinical experiences, and statistical analyses were used to develop the EORTC QLQ-CML24. The final module consists of 24 items assessing the following aspects: symptom burden, impact on daily life and on worry/mood, body image problems, and satisfaction with care and with social life. Internal consistency, assessed with Cronbach’s alpha coefficients, ranged from 0.73 to 0.83 for the proposed scales.ConclusionThe EORTC QLQ-CML24 is an internationally developed HRQOL questionnaire for CML patients, and its implementation in clinical research and practice can provide important information to facilitate clinical decision-making.Keywords: Quality of life, Chronic myeloid leukemia, Questionnaire |
| Databáze: | OpenAIRE |
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