| Autor: |
Kalyani Borde, Mahender Kumar Medisetty, Baby Shalini Muppala, Aishwarya B Reddy, Sireesha Nosina, Manick S. Dass, A. Prashanthi, Pushpanjali Billuri, Dilip Mathai |
| Rok vydání: |
2022 |
| Zdroj: |
IJID Regions. 3:15-20 |
| ISSN: |
2772-7076 |
| Popis: |
There was evidence that antibiotic usage increased in hospitalized COVID-19 patients during the early days of the pandemic.We assessed the impact of stewardship interventions on antibiotic usage in these patients.We designed a quasi-experimental study using an interrupted time series. Patients were stratified according to the severity category of the illness - mild and moderate-to-severe (O2 saturation ≥94% and93% respectively). Baseline antibiotic usage data was collected in the pre-intervention phase. Intervention was given in the form of focus group discussion (FGD) and followed up with feedback-audit during the post-intervention phase. Primary outcome was the change in days of therapy (DOT) per 1000 patient-days.361 adult patients were recruited in both phases during July to December, 2020. In the post-intervention phase, DOT per 1000 patient-days reduced from 589 to 523 (P=0.013) and from 843 to 585 (P0.0001) in mild and moderate-to-severe categories, respectively. De-escalations at 48 hours increased significantly from 21% to 41% (P=0.0079) and from 31% to 62% (P=0.0006), respectively. No difference in mortality was observed.We found high usage of empirical antibiotics in adult patients hospitalized with COVID-19. FGD and feedback audits can successfully reduce antibiotic overuse in these patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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