New Insights of Turmeric Extract-Loaded PLGA Nanoparticles: Development, Characterization and In Vitro Evaluation of Antioxidant Activity
| Autor: | Kátia Aparecida da Silva, Kélin Schwarz, Luciana Facco Dalmolin, Natália Bueno Leite Slade, Camila Maria Gonzales, Jeferson Aparecido Moreto, Renata Fonseca Vianna Lopez |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Antioxidant ABTS Plant Extracts medicine.medical_treatment technology industry and agriculture Nanoparticle Polymer Biodegradable polymer Antioxidants Matrix (chemical analysis) chemistry.chemical_compound Curcuma chemistry Polylactic Acid-Polyglycolic Acid Copolymer Chemistry (miscellaneous) medicine Curcumin Zeta potential Nanoparticles Particle Size Food Science Nuclear chemistry |
| Zdroj: | Plant foods for human nutrition (Dordrecht, Netherlands). 76(4) |
| ISSN: | 1573-9104 |
| Popis: | Here, we presented new insights of the development of poly(lactic-co-glycolic acid) nanoparticles containing turmeric compounds (turmeric-PLGA-NPs) using emulsion-solvent evaporation method. The nanoparticulate system was characterized by size, zeta potential, morphology, release profile, partition parameter, stability and encapsulation efficiency (%EE). Antioxidant activity studies were also evaluated. The Korsmeyer-Peppas model (Mt/M∞ vs. t) was used to determine the release mechanisms of the studied system. Our results demonstrated the emulsion-solvent evaporation method was shown advantageous for producing turmeric-PLGA-NPs in the range of 145 nm with high homogeneity in size distribution, zeta potential of -21.8 mV and %EE about 72%. Nanoparticles were stable over a period of one month. In vitro study showed a release of curcumin governed by diffusion and relaxation of the polymeric matrix. The partition parameter of the extract in relation to blank-PLGA-NPs was 0.111 ± 0.008 M-1, indicating a low affinity of curcumin for the polymer matrix. Antioxidant ability of the turmeric-PLGA-NPs in scavenging the radical 2,2-azinobis (3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) was inferior to free turmeric extract and showed a concentration and time-dependent profile. The study concluded that PLGA nanoparticles are potential carriers for turmeric extract delivery. |
| Databáze: | OpenAIRE |
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