Mortality of patients examined at a diagnostic centre: A matched cohort study
| Autor: | Henrik Møller, Esben Næser, Ulrich Fredberg, Peter Vedsted |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Epidemiology Denmark Comorbidity Disease Cancer Care Facilities Danish Young Adult 03 medical and health sciences 0302 clinical medicine Matched cohort Neoplasms Internal medicine medicine Humans Registries 030212 general & internal medicine Mortality Referral and Consultation Aged Retrospective Studies Aged 80 and over business.industry Hazard ratio Confounding Cancer Retrospective cohort study Middle Aged Prognosis medicine.disease language.human_language Survival Rate Socioeconomic Factors Oncology 030220 oncology & carcinogenesis language Female business |
| Zdroj: | Næser, E, Møller, H, Fredberg, U & Vedsted, P 2018, ' Mortality of patients examined at a diagnostic centre: A matched cohort study ', Cancer epidemiology, vol. 55, pp. 130-135 . https://doi.org/10.1016/j.canep.2018.06.008 |
| ISSN: | 1877-7821 |
| Popis: | Background ‘Diagnostic Centres’ has been established to provide a diagnostic pathway for patients with non-specific, serious symptoms that could be cancer. As little is known about the prognosis, we aimed to 1) analyse mortality of patients examined at the diagnostic centre, stratified on diagnostic outcome (cancer, serious-non-malignant disease, or other/no diagnosis), and 2) compare mortality for cancer patients examined at the diagnostic centre with cancer patients diagnosed through other routes. Method Retrospective cohort study including 938 patients examined at the Diagnostic Centre, Silkeborg Regional Hospital, Denmark, during 2012–2014. Cancer patients examined at the diagnostic centre were matched (1:10) to a reference group of cancer patients diagnosed through other routes. Information on diagnosis, death, comorbidity and socioeconomic factors was obtained by linkage to national Danish registers. Mortality was assessed by Kaplan Meier mortality survival analysis and hazard ratios of death were estimated using Cox proportional regression analysis while adjusting for confounders. Results The 1-year cumulative mortality was 28% in cancer patients examined at the diagnostic centre. The hazard ratio of death was seven times increased in cancer patients compared to patients with other/no diagnosis. The hazard ratio of death was 0.91 (95% CI: 0.68; 1.22) in cancer patients examined at the diagnostic centre compared to cancer patients diagnosed through other routes. Discussion The mortality among cancer patients examined at the diagnostic centre was comparable to cancer patients diagnosed through other routes. The results indicate that cancer patients with non-specific serious symptoms do not have a worse prognosis than other cancer patients. |
| Databáze: | OpenAIRE |
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