Bridging Anxiety and Depression: A Network Approach in Anxious Adolescents
| Autor: | Sarah A. Mossman, Heidi K. Schroeder, Eric T. Dobson, Kim M. Cecil, Paul E. Croarkin, Jeffrey R. Strawn, Sara T. Varney |
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| Rok vydání: | 2021 |
| Předmět: |
Generalized anxiety disorder
Adolescent Demographics Precuneus Anxiety Article 03 medical and health sciences 0302 clinical medicine medicine Humans Default mode network Depressive Disorder Major Depression business.industry medicine.disease Anxiety Disorders 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies medicine.anatomical_structure Major depressive disorder Observational study medicine.symptom business 030217 neurology & neurosurgery Network approach Clinical psychology |
| Zdroj: | J Affect Disord |
| ISSN: | 0165-0327 |
| Popis: | Background The phenomenology and neurobiology of depressive symptoms in anxious youth is poorly understood. Methods Association networks of anxiety and depressive symptoms were developed in adolescents with generalized anxiety disorder (GAD; N=52, mean age: 15.4±1.6 years) who had not yet developed major depressive disorder. Community analyses were used to create consensus clusters of depressive and anxiety symptoms and to identify “bridge” symptoms between the clusters. In a subset of this sample (n=39), correlations between cortical thickness and depressive symptom severity was examined. Results Ten symptoms clustered into an anxious community, 5 clustered into a depressive community and 5 bridged the two communities: impaired schoolwork, excessive weeping, low self-esteem, disturbed appetite, and physical symptoms of depression. Patients with more depressive cluster burden had altered cortical thickness in prefrontal, inferior and medial parietal (e.g., precuneus, supramarginal) regions and had decreases in cortical thickness-age relationships in prefrontal, temporal and parietal cortices. Limitations Data are cross-sectional and observational. Limited sample size precluded secondary analysis of comorbidities and demographics. Conclusions In youth with GAD, a sub-set of symptoms not directly related to anxiety bridge anxiety and depression. Youth with greater depressive cluster burden had altered cortical thickness in cortical structures within the default mode and central executive networks. These alternations in cortical thickness may represent a distinct neurostructural fingerprint in anxious youth with early depressive symptoms. Finally, youth with GAD and high depressive symptoms had reduced age-cortical thickness correlations. The emergence of depressive symptoms in early GAD and cortical development may have bidirectional, neurobiological relationships. |
| Databáze: | OpenAIRE |
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