Organs-on-chips: research and commercial perspectives
| Autor: | Vaibhav Sivaramakrishan, Aarathi Balijepalli |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology Biomedical Research Tissue Engineering Cellular architecture business.industry 03 medical and health sciences 030104 developmental biology Drug development Lab-On-A-Chip Devices Drug Discovery Animals Humans Medicine Biochemical engineering Drug testing methods business Toxicity profile |
| Zdroj: | Drug Discovery Today. 22:397-403 |
| ISSN: | 1359-6446 |
| DOI: | 10.1016/j.drudis.2016.11.009 |
| Popis: | Traditional preclinical drug testing methods utilize animal models to predict pharmacology and toxicology profiles. However, the data obtained from such methods cannot be directly extrapolated to humans and often do not provide a safe starting dose for first-in-human studies. To overcome these limitations, researchers have developed organs-on-chips - microfluidic devices that can mimic the cellular architecture and physiology more accurately than conventional methods. Because accurate organ-level interactions can be achieved with these devices, they have the potential to provide a realistic determination of a drug's pharmacokinetics, pharmacodynamics and toxicity profile. In this review, we describe the evolution of the technology and provide an overview of its current applications. We also discuss the current industry and government initiatives in promoting further research on organs-on-chips for potential use during drug development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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