Synthesis of four spacer-containing 'tetrasaccharides' that represent four possible repeating units of the capsular polysaccharide of Streptococcus pneumoniae type 6B
| Autor: | Mark J. L. Thijssen, Menno H.G. Bijkerk, Johannes F.G. Vliegenthart, Johannis P. Kamerling |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
Serotype Organic Chemistry Molecular Sequence Data Polysaccharides Bacterial Oligosaccharides General Medicine Scheikunde Polysaccharide Hydrogen phosphate medicine.disease_cause Biochemistry Analytical Chemistry Microbiology Streptococcus pneumoniae chemistry Carbohydrate Sequence medicine Carbohydrate Conformation Bacterial Capsules |
| Zdroj: | Carbohydrate research, 306(1-2), 111. Elsevier |
| ISSN: | 0008-6215 |
| Popis: | In the framework of studies towards oligosaccharide-conjugate based vaccines against Streptococcus pneumoniae, the synthesis is reported of four spacer-containing tetrasaccharides that each can be conceived as representing a repeating unit of the capsular polysaccharide of S. pneumoniae serotype 6B, namely, 3-aminopropyl D-ribityl-(5--hydrogen phosphate--2)-alpha-D-galactopyranosyl-(1--3) -alpha-D-glucopyranosyl-(1--3)-alpha-L-rhamnopyranoside, 3-aminopropyl alpha-L-rhamnopyranosyl-(1--4)-D-ribityl-5(--hydrogen phosphate--2)-alpha-D-galactopyranosyl-(1--3)-alpha-D-glucopyranoside, 3-aminopropyl alpha-D-glucopyranosyl-(1--3)-alpha-L-rhamnopyranosyl-(1--4) -D-ribityl-(5--hydrogen phosphate--2) -alpha-D-galactopyranoside, and alpha-D-galactopyranosyl-(1--3)-alpha-D-glucopyranosyl-(1--3)-alpha-L -rhamnopyranosyl-(1--4)-5-O-(3-aminopropyl hydrogen phosphate)-D-ribitol. Phosphorylations were carried out using the H-phosphonate method. |
| Databáze: | OpenAIRE |
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