Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis
| Autor: | Rebecca Balira, Enrique Galban, Sandy Nerette, David Mabey, Rosanna W. Peeling, J Li, Patrice Joseph, R. C. Ballard, Dean Everett, Daniel W. Fitzgerald, Adele Schwartz Benzaken, Heping Zheng, J Changalucha |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Sexually transmitted disease medicine.medical_specialty Adolescent Point-of-Care Systems Prenatal diagnosis Dermatology urologic and male genital diseases Sensitivity and Specificity Rapid plasma reagin Serology Syphilis Serodiagnosis Pregnancy Prenatal Diagnosis Internal medicine Humans Medicine Prospective Studies Syphilis Pregnancy Complications Infectious Rapid Diagnostics medicine.diagnostic_test business.industry Gold standard (test) Middle Aged medicine.disease Surgery Infectious Diseases Female business Treponematosis |
| Zdroj: | Sexually Transmitted Infections. 82:v13-v16 |
| ISSN: | 1368-4973 |
| Popis: | Objectives: To evaluate prospectively four rapid, point-of-care serological tests for syphilis in prenatal or high risk populations in four countries. Methods: Tests were performed on consecutive clinic attenders, using whole blood in the clinic, and whole blood and serum in the laboratory. The sensitivity and specificity of each test was evaluated, using a standard treponemal test ( Treponema pallidum haemagglutination assay (TPHA) or fluorescent treponemal antibody, absorbed (FTA-ABS) as gold standard. Non-treponemal tests (rapid plasma reagin (RPR) or venereal diseases research laboratory (VDRL) tests) were also performed on all subjects at three sites. Results: The specificity of each rapid test was >95% at each site. Sensitivities varied from 64–100% and, in most cases, were lower when whole blood was used rather than serum. Conclusions: Rapid serological tests for syphilis are an acceptable alternative to conventional laboratory tests. Since they do not require equipment or electricity, they could increase coverage of syphilis screening, and enable treatment to be given at the first clinic visit. |
| Databáze: | OpenAIRE |
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