Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse
| Autor: | Ntinginya, Nyanda Elias, Bakuli, Abhishek, Mapamba, Daniel, Sabiiti, Wilber, Kibiki, Gibson, Minja, Lilian Tina, Kuchaka, Davis, Reither, Klaus, Phillips, Patrick Peter John, Boeree, Martin Johan, Gillespie, Stephen H, Hoelscher, Michael, Heinrich, Norbert, Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA) Consortium |
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| Přispěvatelé: | University of St Andrews. Infection and Global Health Division, University of St Andrews. School of Medicine, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Centre for Biophotonics, University of St Andrews. Global Health Implementation Group, University of St Andrews. Gillespie Group, University of St Andrews. Biomedical Sciences Research Complex |
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
NDAS Medical and Health Sciences Microbiology All institutes and research themes of the Radboud University Medical Center Rare Diseases SDG 3 - Good Health and Well-being Recurrence Clinical Research Humans Tuberculosis Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA) Consortium MCC relapse Sputum clinical trial QR Microbiology Mycobacterium tuberculosis Biological Sciences Bacterial Load QR tuberclosis lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Emerging Infectious Diseases Orphan Drug Good Health and Well Being Infectious Diseases biomarker Infection |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 76, iss 3 Clinical Infectious Diseases, 76, e990-e994 Clinical Infectious Diseases, 76, 3, pp. e990-e994 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Funding: this work was supported by several funding agencies. The PanACEA MAMS study was funded by the European and Developing Countries Clinical Trials Partnership (EDCTP1); Grant No. IP.2007.32011.013, IP.2007.32011.012, and IP.2007.32011.011 as well as by the German Ministry of Education and Research (01KA0901). This analysis was funded by the German Center for Infection Research (DZIF); grant no. 02.702. Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8. Publisher PDF |
| Databáze: | OpenAIRE |
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