Comparison of topical fractional CO2 laser and vaginal estrogen for the treatment of genitourinary syndrome in postmenopausal women: a randomized controlled trial
| Autor: | Fernanda Kesselring Tso, Paula Fernanda Santos Pallone Dutra, Neila Maria de Góis Speck, Gustavo Rubino de Azevedo Focchi, Bruna Cristine de Almeida, Stella Catunda Pinho, Ivaldo Silva, Thais Heinke |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
General Mathematics Urology 030209 endocrinology & metabolism Physical examination Vaginal estrogen law.invention 03 medical and health sciences 0302 clinical medicine Atrophy Randomized controlled trial law medicine Humans Aged 030219 obstetrics & reproductive medicine medicine.diagnostic_test Genitourinary system business.industry Applied Mathematics Obstetrics and Gynecology Estrogens Middle Aged medicine.disease Postmenopause Menopause Vagina Lasers Gas Female Amenorrhea medicine.symptom Sexual function business |
| Zdroj: | Menopause. 28:756-763 |
| ISSN: | 1530-0374 |
| DOI: | 10.1097/gme.0000000000001797 |
| Popis: | OBJECTIVE To compare the efficacy of fractional CO2 laser therapy with topical estrogen therapy for the treatment of postmenopausal genitourinary syndrome of menopause. METHODS We conducted a randomized controlled clinical trial involving 25 postmenopausal women. Participants were aged between 50 and 65 years with at least 1 year of amenorrhea and follicle-stimulating hormone levels of >40 IU/L. The women were randomized into two groups: the laser therapy group (n = 13) and the vaginal topical estrogen therapy group (n = 12). Changes in the vaginal epithelium thickness, Frost index, and cell maturation were analyzed in both the groups. The female sexual quotient of each woman was also evaluated. Subjective evaluation was performed through a physical examination. RESULTS Histological analysis showed a significant increase in the vaginal epithelium thickness at the end of treatment in females in both the laser therapy (P |
| Databáze: | OpenAIRE |
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