Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis
| Autor: | Sheng-Li Chen, Li-Na Zhang, Xian-Wei Zhang, Yong-Ping Chen, Jing Guo, Chang-Qing Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
autophagy
Necrosis Neuropsychiatric Disease and Treatment business.industry Autophagy apoptosis Ischemia Stimulation Pharmacology medicine.disease Neuroprotection vagal nerve stimulation cerebral ischemia–reperfusion injury 030227 psychiatry 03 medical and health sciences 0302 clinical medicine Apoptosis Neuroplasticity Medicine medicine.symptom business Reperfusion injury 030217 neurology & neurosurgery Original Research |
| Zdroj: | Neuropsychiatric Disease and Treatment |
| ISSN: | 1178-2021 |
| Popis: | Li-Na Zhang,1,* Xian-Wei Zhang,1,* Chang-Qing Li,2 Jing Guo,1 Yong-Ping Chen,1 Sheng-Li Chen1 1Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheng-Li ChenDepartment of Neurology, Chongqing University Three Gorges Hospital, Number 165 Xincheng Road, Wanzhou District, Chongqing, 404000, People’s Republic of ChinaTel +86 58103452Fax +86 58103668Email chenshengli965@163.comBackground: Cumulative evidence suggests that neuronal death including autophagy, apoptosis, and necrosis is closely related to the occurrence and development of cerebral ischemia–reperfusion (I/R) injury. Moreover, vagal nerve stimulation (VNS) is involved in many different neuroprotective and neuroplasticity pathways. Thus, VNS may be a novel approach for treating various neurodegenerative diseases. The present study aims to determine whether VNS protects against cerebral I/R injury in rats by inhibiting autophagy and apoptosis.Methods: Cerebral I/R injury is induced by middle cerebral artery occlusion (MCAO) and VNS is carried out. Infarct volume, neurological deficit, autophagy, and apoptosis are examined 24 h after reperfusion.Results: Vagal nerve stimulation decreases infarct volume and suppresses neurological deficit. Moreover, obvious autophagy and apoptosis are detected in rats that have undergone I/R, and VNS inhibits autophagy and apoptosis.Conclusion: Vagal nerve stimulation exerts neuroprotective effects following I/R injury by inhibiting autophagy and apoptosis.Keywords: vagal nerve stimulation, cerebral ischemia–reperfusion injury, autophagy, apoptosis |
| Databáze: | OpenAIRE |
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