Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study
| Autor: | Edrisa Mutebi, Martin Muddu, Charles Mondo Kiiza, Frank Mulindwa, Isaac Ssinabulya, Samuel Kizito |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty microalbuminuria Adolescent Cross-sectional study 030231 tropical medicine Logistic regression 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Albumin creatinine microalbuminuria diabetic patients Uganda Internal medicine Diabetes mellitus Prevalence medicine Albuminuria Humans Mass Screening Uganda Glycated Hemoglobin Creatinine business.industry Albumin creatinine Articles General Medicine Middle Aged medicine.disease 3. Good health diabetic patients Cross-Sectional Studies Blood pressure Diabetes Mellitus Type 2 chemistry Female Microalbuminuria Glycated hemoglobin medicine.symptom business Biomarkers |
| Zdroj: | African Health Sciences; Vol 19, No 1 (2019); 1607-1616 African Health Sciences |
| ISSN: | 1680-6905 |
| Popis: | Background: The aim of this study was to determine the prevalence and factors associated with microalbuminuria among newly diagnosed diabetic patients in Mulago National Referral Hospital, Uganda. Methods: In this cross-sectional study conducted between June 2014 and January 2015, we collected information on patients' socio-demographics, biophysical profile, blood pressure, biochemical testing and echocardiographic findings using a pre-tested questionnaire. Bivariate and multivariate logistic regression analyses were used to investigate the association of several factors with microalbuminuria. Results: Of the 175 patients recruited, males were 90(51.4%) and the mean age was 46±15 years. Majority of patients had type 2 DM 140 (80.0%) and the rest had type 1 DM 35 (20.0%). Mean glycated hemoglobin (HbA1C) was 13.9±5.3%. Mean duration of diabetes was 2 months. Prevalence of microalbuminuria was 47.4 % (95% CI: 40.0%-54.9%) overall. Pregnancy was associat- ed with microalbuminuria (OR7.74[95%CI.1.01-76.47] P=0.050) while mild and moderate physical activity at work were inverse- ly associated with microalbuminuria respectively (OR0.08[95%CI0.01-0.95] P=0.046) and (OR0.07[95%CI0.01-0.77] P=0.030). Conclusion: Prevalence of microalbuminuria was high in this group. Physical activity at work may be protective against micro- albuminuria and this calls for longitudinal studies. Early detection and management of microalbuminuria in diabetics may slow progression to overt diabetic nephropathy (DN). Keywords: Albumin, creatinine, microalbuminuria, diabetic patients, Uganda. |
| Databáze: | OpenAIRE |
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