Comparison of stimulation with clomiphene citrate in combination with recombinant follicle-stimulating hormone and recombinant luteinizing hormone to stimulation with a gonadotropin-releasing hormone agonist protocol: a prospective, randomized study

Autor: Christoph Kindermann, Gunda Poschalko, Wilfried Feichtinger, Michaela Pöhl, Monika Weigert, Ursula Krischker
Rok vydání: 2002
Předmět:
Adult
Male
endocrine system
medicine.medical_specialty
Pregnancy Rate
medicine.drug_class
Ovarian hyperstimulation syndrome
Controlled ovarian hyperstimulation
Biology
Clomiphene
Andrology
Gonadotropin-Releasing Hormone
Follicle-stimulating hormone
Ovarian Hyperstimulation Syndrome
Ovulation Induction
Clomifene
Pregnancy
Internal medicine
Gonadotropin-releasing hormone agonist
medicine
Humans
Prospective Studies
Incidence
Pregnancy Outcome
Obstetrics and Gynecology
Fertility Agents
Female
Luteinizing Hormone
medicine.disease
Embryo Transfer
Hormones
Recombinant Proteins
Pregnancy rate
Endocrinology
Reproductive Medicine
Oocytes
Tissue and Organ Harvesting
Drug Therapy
Combination
Female
Gonadotropin
Follicle Stimulating Hormone
Luteinizing hormone
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Zdroj: Fertility and sterility. 78(1)
ISSN: 0015-0282
Popis: Objective: To compare IVF-ET outcome with a new stimulation protocol using clomiphene citrate (CC) with recombinant FSH and LH to stimulation with the standard long GnRH-a protocol. Design: Prospective randomized study. Setting: Outpatient infertility clinic in Vienna, Austria. Patient(s): Two hundred ninety-four infertile women undergoing IVF-ET; 154 IVF cycles stimulated with CC + recombinant FSH + recombinant LH (group A) and 140 cycles with long GnRH-a suppression + recombinant FSH (group B). Intervention(s): Controlled ovarian hyperstimulation, egg retrieval, and ET. Main Outcome Measure(s): Cycle parameters (number of oocytes, fertilization, number of embryos) and outcome (pregnancy rate, cancellation rate, ovarian hyperstimulation syndrome [OHSS]). Result(s): Pregnancy rate per ET was 42.9% (implantation rate, 21.3%) in group A and 36.6% (17.4%) in group B. Cancellation rates were similar. The OHSS occurred in four cases (3%) in group A and 12 cases (10%) in group B. Conclusion(s): Stimulation with CC + recombinant FSH + recombinant LH leads to comparable pregnancy rates vs. the long protocol. With this new stimulation, less gonadotropins are used and there is less need for monitoring (lower cost for patient and clinic). The risk of OHSS is reduced as well. Therefore, this protocol should be regarded as the first-line treatment.
Databáze: OpenAIRE
Externí odkaz: