High-Fat Diet Enhances the Liver Metastasis Potential of Colorectal Cancer through Microbiota Dysbiosis

Autor:	Yina Yu, Yangke Cai, Bin Yang, Siyuan Xie, Wenjuan Shen, Yaoyi Wu, Ziqi Sui, Jianting Cai, Chao Ni, Jun Ye
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Cancer Research Oncology digestive oral and skin physiology colorectal cancer liver metastasis high-fat diet microbiota dysbiosis Desulfovibrio tumour microenvironment digestive system diseases
Zdroj:	Cancers; Volume 14; Issue 11; Pages: 2573
ISSN:	2072-6694
DOI:	10.3390/cancers14112573
Popis:	Obesity, metabolic changes, and intestinal microbiota disruption significantly affect tumorigenesis and metastasis in colorectal cancer (CRC). However, the relationships among these factors remain poorly understood. In this study, we found that a high-fat diet (HFD) promoted gut barrier dysfunction and inflammation in the colorectum and liver. We further investigated gut microbiota changes through 16S rRNA sequencing of faecal samples from HFD-fed rats and CRC hepatic metastasis patients and found an abundance of Desulfovibrio (DSV). DSV could also induce barrier dysfunction in the colorectum and inflammation in the colorectum and liver, suggesting that it contributes to the formation of a microenvironment conducive to CRC tumorigenesis and metastasis. These findings highlight that HFD-induced microbiota dysbiosis, especially DSV abundance, could promote CRC initiation and metastasis.
Databáze:	OpenAIRE
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