Perioperative changes in serum CA125 levels: a prognostic factor for disease-specific survival in patients with ovarian cancer
| Autor: | Marc P.M.L. Snijders, Nienke Zwakman, Roy F.P.M. Kruitwagen, Petra L.M. Zusterzeel, Leon F.A.G. Massuger, Rafli van de Laar, Toon Van Gorp, Isabel Ferreira |
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| Přispěvatelé: | RS: GROW - R2 - Basic and Translational Cancer Biology, Promovendi ODB, Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Neoplasm Residual endocrine system diseases Survival SURGERY medicine.medical_treatment Carcinoma Ovarian Epithelial 0302 clinical medicine RESIDUAL DISEASE Neoplasms Glandular and Epithelial Postoperative Period Stage (cooking) CA-125 Ovarian Neoplasms Univariate analysis 030219 obstetrics & reproductive medicine Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] Obstetrics and Gynecology Obstetrics & Gynecology General Medicine Cytoreduction Surgical Procedures Middle Aged Debulking Prognosis female genital diseases and pregnancy complications Tumor Burden Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] Editorial 030220 oncology & carcinogenesis Residual SURGICAL-TREATMENT Biomarker (medicine) Regression Analysis Original Article Female Life Sciences & Biomedicine medicine.medical_specialty 03 medical and health sciences Internal medicine medicine Humans Aged Neoplasm Staging Retrospective Studies Chemotherapy DECLINE Science & Technology business.industry Ovary Retrospective cohort study Perioperative medicine.disease Surgery SIZE CYTOREDUCTIVE SURGERY CA-125 Antigen Neoplasm business Ovarian cancer Biomarkers |
| Zdroj: | Journal of Gynecologic Oncology Journal of Gynecologic Oncology, 28, 1, pp. e7 Journal of Gynecologic Oncology, 28, e7 Journal of Gynecologic Oncology, 28(1):7. Korean Society of Gynecologic Oncology and Colposcopy |
| ISSN: | 2005-0399 2005-0380 |
| Popis: | OBJECTIVE: In patients with advanced stage epithelial ovarian cancer (EOC) the volume of residual tumor after debulking is known as prognostic factor for survival. We wanted to examine the relationship between postoperative decline in serum CA125 and residual disease after cytoreductive surgery and evaluate perioperative changes in serum CA125 levels as predictor for disease-specific survival. METHODS: A retrospective study was conducted of patients with FIGO stage IIb-IV EOC treated with cytoreductive surgery, followed by chemotherapy between 1996 and 2010 in three hospitals in the Southeastern region of the Netherlands. Data were analyzed with the use of multilevel linear regression and Cox-proportional hazard regression models. RESULTS: A postoperative decline in serum CA125 level of ≥80% was associated with complete primary cytoreduction (p=0.035). Univariate analyses showed favorable associations with survival for both the degree of decline in serum CA125 and residual tumor after primary cytoreduction. In multivariate analyses the decline in serum CA125 but not the outcome of surgery remained significantly associated with better survival (HR(50%-79%)=0.52 [95% CI: 0.28-0.96] and HR(≥80%)=0.26 [95% CI: 0.13-0.54] vs. the serum CA125 decline of |
| Databáze: | OpenAIRE |
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