Sarcopenia and Systemic Inflammation Synergistically Impact Survival in Oral Cavity Cancer
| Autor: | Yu-Ming Huang, Yu-Jen Chen, Jie Lee, Yi-Shing Leu, Shih-Hua Liu, K.Y. Dai, John Chun-Hao Chen, Chung Ji Liu, Chi-Jung Li |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Sarcopenia Systemic inflammation Gastroenterology Risk Assessment Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Stage (cooking) Muscle Skeletal Neoplasm Staging Retrospective Studies Inflammation Mouth Proportional hazards model business.industry Squamous Cell Carcinoma of Head and Neck Hazard ratio Cancer Odds ratio Chemoradiotherapy Adjuvant Middle Aged medicine.disease Prognosis Confidence interval 030104 developmental biology C-Reactive Protein Otorhinolaryngology 030220 oncology & carcinogenesis Female Mouth Neoplasms medicine.symptom Neoplasm Recurrence Local business Tomography X-Ray Computed Follow-Up Studies |
| Zdroj: | The LaryngoscopeReferences. 131(5) |
| ISSN: | 1531-4995 |
| Popis: | OBJECTIVES Sarcopenia and systemic inflammation can affect survival of advanced-stage oral squamous cell carcinoma (OSCC) patients; however, their reciprocal associations with survival outcomes are yet to be investigated. STUDY DESIGN Retrospective review at a tertiary cancer center. METHODS Patients with stage III-IVB OSCC that underwent surgery and (chemo)radiotherapy at our institution between 2010 and 2015 were reviewed. Skeletal muscle index (SMI) was assessed using computed tomography scans at the C3 vertebra. Sarcopenia was defined at the lowest sex-specific tertile for SMI. Systemic inflammation was estimated using the modified Glasgow prognostic score (mGPS), which ranges from 0 to 2 based on serum C-reactive protein and albumin levels. The predictors of overall survival (OS) were evaluated using Cox regression models. RESULTS A total of 174 patients were included in the study. The cut-off values for sarcopenia were set at SMI |
| Databáze: | OpenAIRE |
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