CCR5-Δ32 polymorphism is a genetic risk factor associated with dyslipidemia in patients with type 1 diabetes
| Autor: | Urszula Ławrynowicz, Maria Skrzypkowska, Małgorzata Myśliwiec, Bartosz Słomiński, Jolanta Myśliwska, Monika Ryba-Stanisławowska |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adolescent Receptors CCR5 Immunology Disease Biochemistry 03 medical and health sciences 0302 clinical medicine Gene Frequency Risk Factors Polymorphism (computer science) Internal medicine Diabetes mellitus Genotype medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Risk factor Molecular Biology Dyslipidemias Type 1 diabetes Polymorphism Genetic business.industry nutritional and metabolic diseases Hematology medicine.disease Diabetes Mellitus Type 1 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female business Dyslipidemia |
| Zdroj: | Cytokine. 114:81-85 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2018.11.005 |
| Popis: | In the currently available literature there are no works investigating the correlation between CCR5-Δ32 polymorphism and dyslipidemia in children with type 1 diabetes mellitus (T1D). Therefore, we have decided to explore the potential role played by this polymorphic locus in the incidence of dyslipidemia as an important risk factor for cardiovascular disease (CVD) in patients with T1D.A total of 380 patients with T1D were selected. Patients were divided into two groups: 180 patients with diabetic dyslipidemia and 200 controls without dyslipidemia. Characterization of CCR5-Δ32 genotypes was analyzed by polymerase chain reaction. Logistic regression model was used to examine the association between CCR5-Δ32 polymorphism and dyslipidemia.When participants were analyzed according to CCR5-Δ32 polymorphism, Δ32 carriers presented higher levels of: HbA1c (p 0.001), fasting plasma glucose (p 0.001), LDL (p = 0.02) as well as TG (p = 0.01) and lower levels of HDL (p = 0.01) than noncarriers. Moreover, the minor allele Δ32 was more frequent in dyslipidemic subjects than controls (p 0.001) and conferred an increased individual risk for dyslipidemia (OR = 2.327; 95% CI = 11.241-4.365; p = 0.009).The findings of our study suggest that the CCR5-Δ32 polymorphism is associated with elevated plasma lipid levels and the Δ32 allele increases the risk of dyslipidemia in patients with T1D. Identification of the functional variant underlying these associations may potentially lead to the development of a novel and adjunctive approach for the treatment of dyslipidemia and CVD. |
| Databáze: | OpenAIRE |
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