Increased Intestinal Marker Absorption Due to Regional Permeability Changes and Decreased Intestinal Transit during Sepsis in the Rat
| Autor: | B. Karlsson, Quan Wang, Bengt Jeppsson, Björn Weström, N. Pantzar |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Ovalbumin Inflammation Urine Intestinal absorption Bacteroides fragilis Rats Sprague-Dawley Sepsis In vivo Internal medicine medicine Animals Gastrointestinal Transit Edetic Acid Escherichia coli Infections biology Gastroenterology Bacteroides Infections medicine.disease biology.organism_classification Chromium Radioisotopes In vitro Rats Endocrinology Intestinal Absorption Immunology biology.protein medicine.symptom |
| Zdroj: | Scandinavian Journal of Gastroenterology. 29:1001-1008 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529409094877 |
| Popis: | The intestinal barrier properties are impaired during inflammation and sepsis, but the mechanisms behind this are unknown and were therefore investigated during experimental sepsis in rats.The different-sized intestinal absorption markers 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) and ovalbumin were gavaged to rats made septic by intra-abdominal bacterial implantation and to sham-operated rats. Regional tissue permeability was measured in diffusion chambers, and intestinal transit was evaluated by intestinal accumulation of gavaged 51Cr-EDTA.In comparison with the sham-operated rats, septic rats had higher 51Cr-EDTA levels in blood and urine and showed a prolonged intestinal transit. Septic rats also had a lower tissue permeability to both markers in the small intestines but higher permeability to ovalbumin in the colon. Rats receiving morphine to decrease intestinal motility showed similar changes, with a decreased intestinal transit and increased marker absorption.The results suggest that the increased intestinal absorption during sepsis was due to regional permeability changes and prolonged intestinal transit. |
| Databáze: | OpenAIRE |
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