Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis

Autor: J. Y. Feng, Patrick K. Moonan, Leah G. Jarlsberg, Edward A. Graviss, S. Y.G. Lin, Kenneth C. Jost, Jordan Rose, Michael Ann Janes, M. K. Soehnlen, E. Desmond, Philip C. Hopewell, K. Salcedo, Midori Kato-Maeda, Payam Nahid, James G. Flood, Dennis Osmond
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Antitubercular Agents
Drug Resistance
Cardiorespiratory Medicine and Haematology
medicine.disease_cause
molecular epidemiology
California
Drug Resistance
Multiple
Bacterial
Tuberculosis
Multidrug-Resistant
Genotype
Cluster Analysis
Genetics
Mutation
biology
Isoniazid
Bacterial
transmission
Multidrug-Resistant
Middle Aged
Texas
Infectious Diseases
Female
Rifampin
Infection
Multiple
medicine.drug
Pulmonary and Respiratory Medicine
Adult
Lineage (genetic)
Tuberculosis
030106 microbiology
Microbial Sensitivity Tests
Microbiology
Article
Mycobacterium tuberculosis
Vaccine Related
03 medical and health sciences
Young Adult
Rare Diseases
Bacterial Proteins
Biodefense
medicine
Humans
Molecular epidemiology
business.industry
Prevention
biology.organism_classification
rpoB
medicine.disease
community-based study
Emerging Infectious Diseases
Good Health and Well Being
Antimicrobial Resistance
business
Zdroj: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, vol 21, iss 7
Popis: SETTING: The impact of the genetic characteristics of Mycobacterium tuberculosis on the clustering of multi-drug-resistant tuberculosis (MDR-TB) has not been analyzed together with clinical and demographic characteristics. OBJECTIVE: To determine factors associated with genotypic clustering of MDR-TB in a community-based study. DESIGN: We measured the proportion of clustered cases among MDR-TB patients and determined the impact of clinical and demographic characteristics and that of three M. tuberculosis genetic characteristics: lineage, drug resistance-associated mutations, and rpoA and rpoC compensatory mutations. RESULTS: Of 174 patients from California and Texas included in the study, the number infected by East-Asian, Euro-American, Indo-Oceanic and East-African-Indian M. tuberculosis lineages were respectively 70 (40.2%), 69 (39.7%), 33 (19.0%) and 2 (1.1%). The most common mutations associated with isoniazid and rifampin resistance were respectively katG S315T and rpoB S531L. Potential compensatory mutations in rpoA and rpoC were found in 35 isolates (20.1%). Hispanic ethnicity (OR 26.50, 95%CI 3.73–386.80), infection with an East-Asian M. tuberculosis lineage (OR 30.00, 95%CI 4.20–462.40) and rpoB mutation S531L (OR 4.03, 95%CI 1.05–23.10) were independent factors associated with genotypic clustering. CONCLUSION: Among the bacterial factors studied, East-Asian lineage and rpoB S531L mutation were independently associated with genotypic clustering, suggesting that bacterial factors have an impact on the ability of M. tuberculosis to cause secondary cases.
Databáze: OpenAIRE
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