Current state of ex-vivo lung perfusion
| Autor: | Kristen M. Mackowick, Zachary N. Kon, Pablo G. Sanchez |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030204 cardiovascular system & hematology 030230 surgery Poor quality 03 medical and health sciences 0302 clinical medicine Immunology and Allergy Medicine Lung transplantation Humans Intensive care medicine Donor pool Lung Transplantation business.industry Ex vivo lung perfusion Lung perfusion Tissue Donors Donor lungs Perfusion medicine.anatomical_structure business Lung Transplantation |
| Zdroj: | Current opinion in organ transplantation. 21(3) |
| ISSN: | 1531-7013 |
| Popis: | Purpose of review The purpose of the current report is to review the ex-vivo peer-reviewed literature published in the last 5 years and to summarize the findings. Recent findings Encouraging data have been published by several centers utilizing ex-vivo lung perfusion (EVLP) as a means to identify viable grafts from the high-risk donor pool. The outcomes of transplanted lungs that were initially declined because of poor quality, but reevaluated with ex-vivo perfusion, are equivalent to standard criteria donor lungs. Further, research reports have emphasized the role of ex-vivo perfusion as a platform to improve graft quality and reduce the injurious effects of ischemia-reperfusion. Summary Over the last 10 years, EVLP has proved its value as a reassessment tool to increase donor utilization. As short- and long-term data demonstrate the safety of EVLP, its use as a therapeutic platform is emerging, along with the promise of a new era in lung transplantation. |
| Databáze: | OpenAIRE |
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