Gold-Nanobipyramid-Based Nanotheranostics for Dual-Modality Imaging-Guided Phototherapy
| Autor: | Zhiming Li, Peng Huang, Yashi Li, Liyue Hou, Bhawneeta Nugasur, Yun Yang, Chunxiao Li, Xiaoxia Ding, Jing Lin, Enci Mei, Murong Hu, Cunguo Chen, Yifan Zhang, Zhongqian Su |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Indocyanine Green
Materials science genetic structures Cell Survival Metal Nanoparticles Antineoplastic Agents 02 engineering and technology 010402 general chemistry 01 natural sciences Multimodal Imaging Theranostic Nanomedicine chemistry.chemical_compound Mice Cell Line Tumor medicine Animals Humans General Materials Science Fluorescent Dyes Optical Imaging Cancer Mesoporous silica Photothermal therapy Phototherapy 021001 nanoscience & nanotechnology medicine.disease Tumor tissue 0104 chemical sciences Tumor recurrence chemistry Cancer cell Dual modality Gold 0210 nano-technology Indocyanine green Biomedical engineering |
| Zdroj: | ACS applied materialsinterfaces. 12(11) |
| ISSN: | 1944-8252 |
| Popis: | Multimodality imaging-guided therapy can improve the diagnostics and therapeutics efficiency of cancer. Herein, we developed a light-responsive nanotheranostic agent based on the indocyanine green (ICG) conjugated mesoporous silica coated gold nanobipyramid (GNB@SiO2) (denoted as GNB@SiO2-ICG) for simultaneous fluorescence (FL)/photoacoustic (PA) imaging-guided photothermal therapy (PTT). The GNB@SiO2 with excellent photostability was used for PA imaging as well as PTT. The loaded ICG promised FL imaging and PTT. The feasibility of the cancer theranostic capability of GNB@SiO2-ICG was evaluated from cancer cells to mice. Under the guidance of FL/PA imaging, GNB@SiO2-ICG exhibited remarkably enhanced therapeutic efficacy, which could eliminate the tumor tissues completely without tumor recurrence. This well-defined nanotheranostic nanoplatform that intelligently integrates dual-modality imaging and phototherapy provides an efficient nanoplatform for cancer nanotheranostics. |
| Databáze: | OpenAIRE |
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