Comparison of oral treatment of uncomplicated urogenital and rectal gonorrhoea with cefuroxime axetil ester or clavulanic acid potentiated amoxycillin (Augmentin)
| Autor: | R K Woudstra, M C Ansink-Schipper, E. Stolz, T. Van Joost, Marc F. Michel, J. van Ulsen, R. Schift |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Nausea Gonorrhea Administration Oral Dermatology Amoxicillin-Potassium Clavulanate Combination Gastroenterology Clavulanic Acids Random Allocation Clavulanic acid Internal medicine medicine Humans Urethritis Cefuroxime Clinical Trials as Topic Probenecid business.industry Therapeutic effect Amoxicillin Middle Aged medicine.disease Cephalosporins Surgery Drug Combinations Infectious Diseases Vomiting Drug Therapy Combination Female medicine.symptom business Research Article medicine.drug |
| Zdroj: | Sexually Transmitted Infections. 62:313-317 |
| ISSN: | 1368-4973 |
| Popis: | In a randomised study of two drugs for the oral treatment of uncomplicated urogenital and rectal gonorrhoea the therapeutic effect of cefuroxime axetil ester (CAE) and amoxycillin plus clavulanic acid (A + C) was compared. Cefuroxime axetil ester 1.5 g was given to 129 men and 118 women. Amoxycillin 3.0 g and clavulanic acid 0.25 g was given to 131 men and 122 women. Both treatments were combined with probenecid 1.0 g and administered in a single oral dose. Of the 500 patients thus treated, 376 were assessable. In the group taking CAE, failure rates were 0.9% for the men and 0% for the women; and the overall failure rate was 0.5%. In the group taking A + C the equivalent failure rates were 4.6%, 1.2%, and 3.1%. The differences were not significant. Penicillinase producing Neisseria gonorrhoeae (PPNG) was isolated from 5.6% of the assessable patients. All 10 PPNG infections in the group taking CAE and four of 11 PPNG infections in the group taking A + C were cured. These numbers were too small to draw a definite conclusion about the efficacy of both drugs in this type of infection. Postgonococcal urethritis was observed in 35% of the men in the group taking CAE and in 32% of those in the group taking A + C. Side effects were noted in 38% of the group taking CAE and 28% of the group taking A + C. Nausea and vomiting were more commonly observed in the group taking CAE; and diarrhoea was more commonly observed in the group taking A + C. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|