Mood Response to Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
| Autor: | Patrick M. Weaver, Joel S. Perlmutter, Meghan C. Campbell, Morvarid Karimi, Heather M. Lugar, Samer D. Tabbal, Kevin J. Black, Tom O. Videen, Tamara Hershey |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Parkinson's disease Deep brain stimulation Deep Brain Stimulation medicine.medical_treatment Stimulation behavioral disciplines and activities Severity of Illness Index Functional Laterality Article Subthalamic Nucleus medicine Humans Electrode placement Aged Pain Measurement medicine.diagnostic_test Parkinson Disease Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases Affect Psychiatry and Mental health Subthalamic nucleus surgical procedures operative Mood nervous system Multivariate Analysis Process description Female Neurology (clinical) Mental Status Schedule Tomography X-Ray Computed Psychology therapeutics Neuroscience |
| Zdroj: | The Journal of Neuropsychiatry and Clinical Neurosciences. 24:28-36 |
| ISSN: | 1545-7222 0895-0172 |
| DOI: | 10.1176/appi.neuropsych.11030060 |
| Popis: | Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) improves motor functioning but has variable effects on mood. Little is known about the relationship between electrode contact location and mood response. The authors identified the anatomical location of electrode contacts and measured mood response to stimulation with the Visual Analog Scale in 24 STN DBS PD patients. Participants reported greater positive mood and decreased anxiety and apathy with bilateral and unilateral stimulation. Left DBS improved mood more than right DBS. Right DBS-induced increase in positive mood was related to more medial and dorsal contact locations. These results highlight the functional heterogeneity of the STN. |
| Databáze: | OpenAIRE |
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