Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study
| Autor: | Lambrini Galani, Kalomira Athanassiou, Nikolaos Anagnostopoulos, Efstathios Papageorgiou, Vladimir Krcmery, E. Panaretou, Panagiotis Repoussis, P. Grecka, Diamantis Plachouras, Michel Aoun, Emilio Bouza, E. Devigili, Evangelos J. Giamarellos-Bourboulis, Helen Giamarellou, Francesco Menichetti, Drgon̂a Lubos |
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| Rok vydání: | 2004 |
| Předmět: |
Bacteramia
C-reactive protein Diagnosis Fever Procalcitonin Adult Aged Bacteremia Bacterial Infections C-Reactive Protein Calcitonin Calcitonin Gene-Related Peptide Female Fever of Unknown Origin Gram-Negative Bacteria Gram-Positive Cocci Humans Male Middle Aged Neutropenia Protein Precursors Sensitivity and Specificity Microbiology (medical) Infectious Diseases medicine.medical_specialty Gastroenterology Internal medicine medicine Fever of unknown origin Leukopenia biology business.industry Acute-phase protein General Medicine medicine.disease bacterial infections and mycoses Immunology biology.protein Bacteraemia medicine.symptom business Febrile neutropenia hormones hormone substitutes and hormone antagonists |
| Zdroj: | Clinical Microbiology and Infection. 10(7):628-633 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2004.00883.x |
| Popis: | In order to assess the diagnostic value of procalcitonin, 158 patients with febrile neutropenia from centres across Europe were studied. Patients with fever were diagnosed on the basis of either: (1) clinical, radiological and microbiological criteria; or (2) the procalcitonin value. In the latter case, concentrations of 0.5–1.0 ng ⁄ mL were considered diagnostic of localised infection, concentrations of 1.0–5.0 ng ⁄ mL of bacteraemia, and concentrations of > 5.0 ng ⁄ mL of severe sepsis. Procalcitonin and C-reactive protein were estimated daily in serum by immunochemiluminescence and nephelometry, respectively. Overall, the sensitivity (specificity) of procalcitonin for bacteraemia was 44.2% (64.3% )a t concentrations of 1.0–5.0 ng ⁄ mL, and 83.3% (100%) for severe sepsis at concentrations of > 5.0 ng ⁄ mL. It was concluded that procalcitonin is a marker strongly suggestive of severe sepsis at concentrations of > 5.0 ng ⁄ mL. Estimated concentrations of < 0.5 ng ⁄ mL indicate that infection is unlikely, but it was observed that bacteraemia associated with coagulase-negative staphylococci may fail to elevate serum procalcitonin levels. |
| Databáze: | OpenAIRE |
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