Non-psychotropic cannabinoids as inhibitors of TET1 protein

Autor:	Veronika Antonyová, Zdeněk Kejík, Tereza Brogyanyi, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Tomáš Ocelka, Michal Masařík, Adam Matkowski, Jakub Gburek, Renata Abel, Andrean Goede, Robert Preissner, Petr Novotný, Milan Jakubek
Rok vydání:	2022
Předmět:	Molecular Docking Simulation Cannabinoids Organic Chemistry Drug Discovery Cannabinol Cannabidiol Ferrous Compounds Molecular Biology Biochemistry Cannabis
Zdroj:	Bioorganic Chemistry. 124:105793
ISSN:	0045-2068
DOI:	10.1016/j.bioorg.2022.105793
Popis:	Non-psychotropic cannabinoids (e.g., cannabidiol, cannabinol and cannabigerol) are contained in numerous alimentary and medicinal products. Therefore, predicting and studying their possible side effects, such as changes in DNA methylation, is an important task for assessing the safety of these products. Interference with TET enzymes by chelating ferrous ions can contribute to the altered methylation pattern. All tested cannabinoids displayed a strong affinity for Fe(II) ions. Cannabidiol and cannabinol exhibited potent inhibitory activities (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555241eb870c8956f1cbfdc78ed9b242 https://doi.org/10.1016/j.bioorg.2022.105793 Zobrazit plný text záznamu Full Text from ScienceDirect