Correlation between insulin resistance and liver histology in patients with nonalcoholic steatohepatitis with and without obesity
| Autor: | Rajesh Gopalakrishna, Ismail Siyad, Harikumar R. Nair, Mathew Vadukoot Lazar, Malini Eapen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Cirrhosis Overweight digestive system Gastroenterology 03 medical and health sciences 0302 clinical medicine Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans medicine.diagnostic_test business.industry Fatty liver nutritional and metabolic diseases Hepatology medicine.disease Obesity digestive system diseases Liver 030220 oncology & carcinogenesis Liver biopsy 030211 gastroenterology & hepatology Female medicine.symptom Insulin Resistance business Body mass index |
| Zdroj: | Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 39(1) |
| ISSN: | 0975-0711 |
| Popis: | Insulin resistance (IR) plays a central role in pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of this study was to correlate histopathological grading and IR in overweight/obese patients with NASH as compared with lean NASH. Patients with NASH who underwent liver biopsy between January 2012 and December 2012 were included. Anthropometric, clinical, and biochemical features, necro-inflammatory grades, and fibrosis stage on liver biopsies were scored according to Brunt and non-alcoholic fatty liver disease (NAFLD) activity score (NAS). Of 42 patients, 33 (78.6%) had body mass index (BMI) ≥ 23 kg/m2 (overweight/obese) while 9 had BMI 2, and NAS scores, and NAS scores 4. Although IR was significantly higher in overweight/obese patients with NASH as compared with that in lean patients with NASH, there was no difference in the correlation of HOMA-IR with histology between these groups. |
| Databáze: | OpenAIRE |
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