Ocular and cardiovascular effects of local and systemic pindolol
| Autor: | S E Smith, F Reynolds, S A Smith, V. B. Whitmarsh |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Tachycardia Intraocular pressure genetic structures Pupil diameter Glaucoma Cellular and Molecular Neuroscience Double-Blind Method Heart Rate Heart rate medicine Humans In patient Pindolol Intraocular Pressure Clinical Trials as Topic business.industry medicine.disease Stimulation Chemical eye diseases Sensory Systems Ophthalmology Heart failure Anesthesia Injections Intravenous Drug Evaluation Female sense organs Ophthalmic Solutions medicine.symptom business Research Article medicine.drug |
| Zdroj: | British Journal of Ophthalmology. 63:63-66 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.63.1.63 |
| Popis: | Ocular and cardiovascular effects of topical and intravenous pindolol have been studied in a balanced cross-0ver double-blind trial in 6 healthy volunteers. When applied to 1 eye pindolol lowered intraocular pressure in both the treated and untreated eyes with only minimal reduction in resting pupil diameter and light reflex response. The concentration in plasma was much lower and inhibiton of exercise tachycardia about half that when the same dose was administered intravenously. The findings suggest that beta-adrenoceptor blocking drugs should not be used in the treatment of glaucoma in patients who also suffer from heart failure. |
| Databáze: | OpenAIRE |
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