Reduced Repair of the Oxidative 8-Oxoguanine DNA Damage and Risk of Head and Neck Cancer
Autor: | Adi Shani, Alain Berrebi, Tamar Paz-Elizur, Edna Schechtman, Meir Krupsky, Laurence S. Freedman, Rami Ben-Yosef, Zvi Livneh, Dalia Elinger, Akiva Vexler |
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Rok vydání: | 2006 |
Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Pathology Guanine DNA Repair Ogg medicine.disease_cause Lesion Reference Values Risk Factors Surveys and Questionnaires Internal medicine medicine Humans Risk factor Lung cancer Aged Neoplasm Staging Aged 80 and over business.industry Head and neck cancer Odds ratio computer.file_format Middle Aged medicine.disease Head and Neck Neoplasms Relative risk Carcinoma Squamous Cell Female medicine.symptom business Oxidation-Reduction computer Oxidative stress DNA Damage |
Zdroj: | Cancer Research. 66:11683-11689 |
ISSN: | 1538-7445 0008-5472 |
Popis: | An increasing number of studies indicate that reduced DNA-repair capacity is associated with increased cancer risk. Using a functional assay for the removal of the oxidative DNA lesion 8-oxoguanine by the DNA-repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1), we have previously shown that reduced OGG activity is a risk factor in lung cancer. Here, we report that OGG activity in peripheral blood mononuclear cells from 37 cases with squamous cell carcinoma of the head and neck (SCCHN) was significantly lower than in 93 control subjects, frequency matched for age and gender. Retesting of OGG activity 3 to 4 years after diagnosis and successful treatment of 18 individuals who recovered from the disease showed that OGG activity values were similar to those determined at diagnosis, suggesting that reduced OGG activity in case patients was not caused by the disease. Logistic regression analysis indicated that the adjusted odds ratio (OR) associated with a unit decrease in OGG activity was statistically significantly increased [OR, 2.3; 95% confidence interval (95% CI), 1.5–3.4]. Individuals in the lowest tertile of OGG activity exhibited an increased risk of SCCHN with an OR of 7.0 (95% CI, 2.0–24.5). The combination of smoking and low OGG was associated with a highly increased estimated relative risk for SCCHN. These results suggest that low OGG is associated with the risk of SCCHN, and if confirmed by additional epidemiologic studies, screening of smokers for low OGG activity might be used as a strategy for the prevention of lung cancer and SCCHN. (Cancer Res 2006; 66(24): 11683-9) |
Databáze: | OpenAIRE |
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