Toll-Like Receptor 4 and Matrix Metalloproteases 11 and 13 as Predictors of Tumor Recurrence and Survival in Stage II Colorectal Cancer
| Autor: | Francisco J. Vizoso, Luis O. González, Sandra Cid, García-Muñiz Jl, Alejandro Andicoechea, Juan Francisco Carrión, Noemi Eiro |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Cancer Research Prognostic variable Cell type Matrix metalloproteinase medicine.disease_cause Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Matrix Metalloproteinase 11 Matrix Metalloproteinase 13 Biomarkers Tumor medicine Humans Neoplasm Metastasis Aged Neoplasm Staging Aged 80 and over Toll-like receptor business.industry General Medicine Middle Aged Prognosis medicine.disease Gene Expression Regulation Neoplastic Survival Rate Toll-Like Receptor 4 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research TLR4 Immunohistochemistry Female Neoplasm Recurrence Local Colorectal Neoplasms Carcinogenesis business Follow-Up Studies |
| Zdroj: | Pathology & Oncology Research. 25:1589-1597 |
| ISSN: | 1532-2807 1219-4956 |
| Popis: | Current clinical-pathologic stratification factors do not allow clear identification of high-risk stage II colorectal cancer (CRC) patients. Therefore, the identification of additional prognostic markers is desirable. Toll-like receptor (TLR)-4 is activated during tumorigenesis and matrix metalloproteases (MMPs) are involved in invasion and metastasis. We aimed to evaluate the expression and clinical relevance of TLR4, MMP11 and MMP13 for patients with stage II CRC. Immunohistochemistry was used to study the expression of TLR4, MMP11 and MMP13 in 96 patients with stage II CRC. We measured the global expression and the expression by different cell types (tumor cells, cancer-associated fibroblasts (CAFs) and mononuclear inflammatory cells (MICs)). The potential relationship between expressions of factors and different prognostic variables were evaluated. Our results show significant relationships between either TLR4 expression by tumor cells and MMP11 expression by CAFs and high risk of tumor recurrence. In addition, the concurrence of age ≥ 75 years and the non-expression of MMP11 by CAFs identify a subgroup of patients with a good prognosis. Our results show that TLR4 expression by tumor cells and MMP11 expression by CAFs may to improve the identification of patients with stage II CRC with a high-risk of relapse. |
| Databáze: | OpenAIRE |
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