Synthesis, characterization, and antitumor activity of 5-iodouracil complexes
| Autor: | Ajit Sodhi, Animesh K. Ghose, Rakesh K. Singh, U. P. Singh, Badri N. Singh |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Spectrophotometry Infrared Stereochemistry Infrared spectroscopy Antineoplastic Agents Biochemistry Inorganic Chemistry Mice X-Ray Diffraction Transition metal In vivo Animals Sarcoma 180 Uracil 5-Iodouracil Antitumor activity Manganese Mice Inbred C3H Molecular Structure Chemistry Electron Spin Resonance Spectroscopy Biological activity Cobalt Neoplasms Experimental In vitro Zinc X-ray crystallography Female Copper Neoplasm Transplantation Cadmium Nuclear chemistry |
| Zdroj: | Journal of Inorganic Biochemistry. 44:277-282 |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/0162-0134(91)84033-6 |
| Popis: | Complexes of 5-iodouracil (5IU) with Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) ions have been prepared, characterized, and subjected to a screening system for evaluation of antitumor activity against Sarcoma-180 (S-180) and L 929 tumor cells. The complexes were characterized by their elemental analysis, infrared spectra, electronic spectra, magnetic measurements, and powder x-ray diffraction. The antitumor activity results indicate that some complexes have good antitumor activity both in vivo and in vitro against S-180 and L 929 tumor cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|