Immunomodulating and anti-tumor action of extracts of several mushrooms
| Autor: | Simbirtsev Andrey S, V. G. Konusova, Nikolay Petrishchev, Nina Denisova, Mark Shamtsyan, Yulia Maksimova, Alexander Goloshchev, Andrey V. Panchenko |
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| Rok vydání: | 2004 |
| Předmět: |
Skin Neoplasms
Neutrophils Antineoplastic Agents Bioengineering Stimulation Pharmacology Biology Applied Microbiology and Biotechnology Proinflammatory cytokine Mice Adjuvants Immunologic In vivo medicine Animals Humans Melanoma Mycelium Antitumor activity Mushroom General Medicine medicine.disease In vitro Immunology Mice Inbred CBA Agaricales Reactive Oxygen Species Neoplasm Transplantation Biotechnology |
| Zdroj: | Journal of Biotechnology. 113:77-83 |
| ISSN: | 0168-1656 |
| DOI: | 10.1016/j.jbiotec.2004.04.034 |
| Popis: | Aqueous extracts from fruit bodies and mycelia of various higher Basidiomycetes were studied in search for reliable biological effects. In vitro and in vivo experiments were conducted. The results showed that the aqueous extracts demonstrated various types of marked biological actions: an increased production of reactive oxygen forms by neutrophil cells of human peripheral blood; a significant mitogenic activity in a wide range of concentrations; stimulation on production of inflammatory cytokines interleukine 1-β and interleukine-8 by peripheral blood cells; a decrease in both average tumor size in mice with transplanted melanoma B16 and a manifestation of tumorous intoxication; and a prolongation in the survival rate of such mice. |
| Databáze: | OpenAIRE |
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