The Role of the Gut-Liver Axis in Metabolic Dysfunction-Associated Fatty Liver Disease
| Autor: | Agustín Albillos, Rosa María Martín-Mateos |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
intestinal microbiota
0301 basic medicine Mini Review Immunology Inflammation Disease Gut flora intestinal immunity Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Non-alcoholic Fatty Liver Disease steatosis medicine Animals Humans Immunology and Allergy Intestinal Mucosa Metabolic Syndrome biology Fatty liver Imidazoles RC581-607 medicine.disease biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Liver metabolic liver disease Sulfoxides CCR5 Receptor Antagonists Dysbiosis 030211 gastroenterology & hepatology gut abnormalities Immunologic diseases. Allergy medicine.symptom Metabolic syndrome Homeostasis |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.660179 |
| Popis: | The complex interplay between the gut microbiota, the intestinal barrier, the immune system and the liver is strongly influenced by environmental and genetic factors that can disrupt the homeostasis leading to disease. Among the modulable factors, diet has been identified as a key regulator of microbiota composition in patients with metabolic syndrome and related diseases, including the metabolic dysfunction-associated fatty liver disease (MAFLD). The altered microbiota disrupts the intestinal barrier at different levels inducing functional and structural changes at the mucus lining, the intercellular junctions on the epithelial layer, or at the recently characterized vascular barrier. Barrier disruption leads to an increased gut permeability to bacteria and derived products which challenge the immune system and promote inflammation. All these alterations contribute to the pathogenesis of MAFLD, and thus, therapeutic approaches targeting the gut-liver-axis are increasingly being explored. In addition, the specific changes induced in the intestinal flora may allow to characterize distinctive microbial signatures for non-invasive diagnosis, severity stratification and disease monitoring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|