Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort
| Autor: | Brian Allwood, R. van Zyl-Smit, J Goldin, Q Said-Hartley, Eric D. Bateman, Rencia Gillespie, Nulda Beyers, C B Cooper, G Calligaro, E. M. van Rikxoort, Mary Bateman, Luís Taborda-Barata, Helena Olckers, Maya Galperin-Aizenberg |
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| Přispěvatelé: | uBibliorum |
| Rok vydání: | 2017 |
| Předmět: |
Spirometry
medicine.medical_specialty Pathology Pulmonology Physiology lcsh:Medicine Context (language use) Chronic airflow obstruction Pulmonary function testing South Africa 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Diffusing capacity Internal medicine medicine Tuberculosis Adults COPD 030212 general & internal medicine Computed tomography GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) lcsh:R5-920 medicine.diagnostic_test business.industry Chronic obstructive pulmonary disease lcsh:R General Medicine respiratory system medicine.disease Obstructive lung disease respiratory tract diseases Phenotype 030228 respiratory system Lung function tests Cohort Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5] Medicine Radiology lcsh:Medicine (General) business |
| Zdroj: | Samj, 107, 440-445 South African Medical Journal; Vol 107, No 5 (2017); 440-445 SAMJ: South African Medical Journal, Volume: 107, Issue: 5, Pages: 440-445, Published: MAY 2017 South African Medical Journal, Vol 107, Iss 5, Pp 440-445 (2017) Samj, 107, 5, pp. 440-445 Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| ISSN: | 0256-9574 2078-5135 |
| Popis: | Background. An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should be viewed as chronic obstructive pulmonary disease (COPD) or a separate phenotype. Objective. To compare lung physiology and high-resolution computed tomography (HRCT) findings in subjects with CAL and evidence of previous (healed) PTB with those in subjects with smoking-related COPD without evidence of previous PTB. Methods. Subjects with CAL identified during a Burden of Obstructive Lung Disease (BOLD) study performed in South Africa were studied. Investigations included questionnaires, lung physiology (spirometry, body plethysmography and diffusing capacity) and quantitative HRCT scans to assess bronchial anatomy and the presence of emphysema (–200 HU). Findings in subjects with a past history and/or HRCT evidence of PTB were compared with those in subjects without these features. Results. One hundred and seven of 196 eligible subjects (54.6%) were enrolled, 104 performed physiology tests and 94 had an HRCT scan. Based on history and HRCT findings, subjects were categorised as no previous PTB (NPTB, n=31), probable previous PTB (n=33) or definite previous PTB (DPTB, n=39). Subjects with DPTB had a lower diffusing capacity (Δ=–17.7%; p=0.001) and inspiratory capacity (Δ=–21.5%; p=0.001) than NPTB subjects, and higher gas-trapping and fibrosis but not emphysema scores (Δ=+6.2% (p=0.021), +0.36% (p=0.017) and +3.5% (p=0.098), respectively). Conclusions. The mechanisms of CAL associated with previous PTB appear to differ from those in the more common smoking-related COPD and warrant further study. |
| Databáze: | OpenAIRE |
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