It Takes Two to Tango: The Role of Dysregulated Metabolism and Inflammation in Kidney Disease Development
| Autor: | Katalin Susztak, Poonam Dhillon, Ghazal Z. Quinn |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
030232 urology & nephrology Inflammation DNA Mitochondrial Oxidative Phosphorylation Article Proinflammatory cytokine Pathogenesis 03 medical and health sciences 0302 clinical medicine Animals Humans Medicine Renal Insufficiency Chronic Kidney Innate immune system urogenital system business.industry Macrophages Fatty Acids Acute kidney injury Complement System Proteins Acute Kidney Injury medicine.disease Immunity Innate Mitochondria Kidney Tubules 030104 developmental biology medicine.anatomical_structure Nephrology Stimulator of interferon genes Cancer research Cytokines medicine.symptom business Kidney disease |
| Zdroj: | Semin Nephrol |
| ISSN: | 0270-9295 |
| Popis: | Acute kidney injury is a major contributor of chronic kidney disease development. The pathogenesis of acute kidney injury and chronic kidney disease shows significant similarities. Both conditions are associated with a defect in cellular metabolism, such as fatty acid oxidation and mitochondrial oxidative phosphorylation in kidney tubule cells and a marked increase in infiltrating immune cells. Here, we discuss how inflammatory cytokines and macrophages contribute to epithelial injury and metabolic defects. In addition, we discuss the role of mitochondrial damage and cytosolic leakage of the mitochondrial DNA activating the innate immune pathway such as cyclic guanosine monophosphate–adenosine monophosphate synthase/stimulator of interferon genes. The interplay between inflammation and metabolism appears to be critical for kidney disease development. |
| Databáze: | OpenAIRE |
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