Swiss clinical practice guidelines for skin cancer in organ transplant recipients

Autor: Günther F.L. Hofbauer, Robert E. Hunger, Andreas L. Serra, Emmanuel Laffitte, Manuel Pascual, Francesco Pelloni, Alexandra Arnold, Isabelle Binet, Mark Anliker, Anne-Karine Lapointe, Werner Kempf
Přispěvatelé: SGDV working group for organ transplant recipients, University of Zurich
Jazyk: angličtina
Rok vydání: 2009
Předmět:
medicine.medical_specialty
Skin Neoplasms
medicine.medical_treatment
Acitretin/therapeutic use
Anticarcinogenic Agents/therapeutic use
Carcinoma
Squamous Cell/immunology
Carcinoma
Squamous Cell/prevention & control
Humans
Immunocompromised Host
Organ Transplantation/adverse effects
Skin Neoplasms/immunology
Skin Neoplasms/prevention & control
Sunscreening Agents/therapeutic use
610 Medicine & health
2700 General Medicine
Organ transplantation
Acitretin
medicine
Carcinoma
Anticarcinogenic Agents
10035 Clinic for Nephrology
ddc:610
Carcinoma
Squamous Cell/immunology/prevention & control
integumentary system
business.industry
Actinic keratosis
10177 Dermatology Clinic
Cancer
Immunosuppression
General Medicine
Organ Transplantation
medicine.disease
Dermatology
Surgery
Transplantation
stomatognathic diseases
Practice Guidelines as Topic
Carcinoma
Squamous Cell
Skin cancer
Skin Neoplasms/immunology/prevention & control
business
Sunscreening Agents
Immunosuppressive Agents
Switzerland
medicine.drug
Zdroj: Swiss medical weekly, vol. 139, no. 29-30, pp. 407-415
Scopus-Elsevier
Günther Hofbauer
Swiss Medical Weekly, Vol. 139, No 29-30 (2009) pp. 407-15
Europe PubMed Central
ISSN: 1424-7860
Popis: Patients with a solid organ transplant have increased in numbers and in individual survival in Switzerland over the last decades. As a consequence of long-term immunosuppression, skin cancer in solid organ recipients (SOTRs) has been recognized as an important problem. Screening and education of potential SOTRs about prevention of sun damage and early recognition of skin cancer are important before transplantation. Once transplanted, SOTRs should be seen by a dermatologist yearly for repeat education as well as early diagnosis, prevention and treatment of skin cancer. Squamous cell carcinoma of the skin (SCC) is the most frequent cancer in the setting of long-term immunosuppression. Sun protection by behaviour, clothing and daily sun screen application is the most effective prevention. Cumulative sun damage results in field cancerisation with numerous in-situ SCC such as actinic keratosis and Bowen's disease which should be treated proactively. Invasive SCC is cured by complete surgical excision. Early removal is the best precaution against potential metastases of SCC. Reduction of immunosuppression and switch to mTOR inhibitors and potentially, mycophenolate, may reduce the incidence of further SCC. Chemoprevention with the retinoid acitretin reduces the recurrence rate of SCC. The dermatological follow-up of SOTRs should be integrated into the comprehensive post-transplant care.
Databáze: OpenAIRE
Externí odkaz: