Genetic control of the human Vβ13.2 T cell repertoire: importance of allelic variation outside the coding regions of theTCRBV13S2 gene

Autor:	A Hajeer, William E. R. Ollier, Neil Snowden, Richard A. Kay, Art W. Boylston
Rok vydání:	1994
Předmět:	Genetics Base Sequence Genotype Receptors Antigen T-Cell alpha-beta Molecular Sequence Data Immunology T-cell receptor Chromosome Mapping Locus (genetics) Human leukocyte antigen Biology Molecular biology Null allele T-Cell Receptor Gene Humans Immunology and Allergy Allele Gene Alleles CD8
Zdroj:	European Journal of Immunology. 24:2863-2867
ISSN:	1521-4141 0014-2980
DOI:	10.1002/eji.1830241142
Popis:	In humans, the T cell repertoire is influenced by HLA, T cell receptor null alleles and antigen. Here, we describe a novel mechanism, independent of superantigen or T cell receptor structure which influences the T cell repertoire in a V beta-dependent manner. We have identified a biallelic locus, the TCRBV13S2 T cell receptor gene, where allelic differences predominate in the non-coding regions including transitions, transversions and frameshift deletions. The expressed protein is non-polymorphic at this locus. The TCRBV13S2 genotype profoundly influences the circulating levels of V beta 13.2 CD4 T cells but does not affect T cell receptor expression or function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553ed8013a5ecb9fe42f9bdd837778c6 https://doi.org/10.1002/eji.1830241142 Zobrazit plný text záznamu Plný text