The effects of intravaginal clindamycin and metronidazole therapy on vaginal mobiluncus morphotypes in patients with bacterial vaginosis
| Autor: | James L. Joffrion, Robert J. Schumacher, Matthew J. McIntosh, Jana I. Steinmetz, Paul Nyirjesy |
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| Rok vydání: | 2006 |
| Předmět: |
Microbiology (medical)
Sexually transmitted disease Adult medicine.medical_specialty medicine.drug_class Antibiotics Dermatology Microbiology Vaginal disease Metronidazole medicine Humans Mobiluncus Antibacterial agent Retrospective Studies Gynecology biology business.industry Clindamycin Public Health Environmental and Occupational Health Vaginosis Bacterial medicine.disease biology.organism_classification Anti-Bacterial Agents Self Care Administration Intravaginal Infectious Diseases Treatment Outcome Female Bacterial vaginosis business Actinomycetales Infections medicine.drug |
| Zdroj: | Sexually transmitted diseases. 34(4) |
| ISSN: | 0148-5717 |
| Popis: | The objective of this study was to compare the effects of treatments for bacterial vaginosis (BV) on vaginal Mobiluncus morphotypes.Analyses were performed on Mobiluncus scores from similarly conducted studies evaluating clindamycin vaginal single-dose cream (CVSDC) or metronidazole vaginal gel (MVG) in 55 patients with BV and with Mobiluncus morphotypes at baseline.Both treatment groups demonstrated significant reductions in Mobiluncus score. However, the Mobiluncus score at test-of-cure was lower in the CVSDC than in the MVG group (P=0.0471). More patients in the CVSDC group than in the MVG group achieved microbiologic (57.5% vs. 26.7%; P=0.04), clinical (57.5% vs. 26.7%; P=0.04), and therapeutic cures of BV (45.0% vs. 20.0%; P=0.09).Clindamycin reduces vaginal Mobiluncus morphotypes to a greater extent than metronidazole in patients with BV; this correlates with a higher BV cure rate. |
| Databáze: | OpenAIRE |
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